Dynamic expression changes of miRNomes and mRNomes

Time-resolved regulation of microRNA expression triggered by external stimuli such as cytokines or hypoxia through activation of specific transcription factors (cancer models: melanoma and hepatocellular carcinoma).

Picture: Circos diagrams showing the dynamical dependency of the transcriptome, inferred upstream regulators (transcription factors) and miRNAs (Nazarov P, Reinsbach S et al., NAR, 2013)