The Neurobiology group is investigating the molecular mechanisms of inflammation and differentiation of glial cells that are relevant during neurodegenerative and inflammatory events of the brain. Three major projects are currently being developed in the lab:

1. Astrocyte differentiation, maturation and phenotype acquisition

  •  Characterization of the different states of astrocytes (mature/immature)   
  •  Investigation of the possible link between the state of maturity and the different phenotypes of astrocytes in the brain.
  •  Epigenomic, transcriptomic and proteomic analyses to define steps of astrocyte differentiation in various in vitro and in vivo models.
  •  Role of inflammation on astrocyte differentiation and astrocyte plasticity.

2. Glial reactivity in a Parkinson’s disease-like context

  • Glial cell cultures (astrocytes, microglia)
  • Activation processes of glial cells after exposure to a-synuclein peptides (wild-type and mutants)
  • Effects of Apomorphine on the a-synuclein-induced microglial reactivity
  • Transcriptomic and proteomic analyses

3. Inflammasome function in neuroinflammation: a role for microglia in Parkinson's disease

  • Function and activation of inflammasome in microglia.
  • Role of IL-1b and the NLRP3 inflammasome in Parkinson’ s disease (transgenic mice models)
  • Metabolomic, transcriptomic and proteomic analyses in macrophages and microglia