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Publications

2020

Koncina, E., Haan, S., Rauh, S., & Letellier, E. (2020, January 30). Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges. Cancers.
Ternes, D., Karta, J., Tsenkova, M., Koncina, E., Schmitz, M., Grandmougin, L., Ginolhac, A., Gaigneaux, A., Ramiro Garcia, J., Wilmes, P., Haan, S., & Letellier, E. (2020, February 22). Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression. Poster session presented at The Microbiome, Viruses, and Cancer, Orlando, USA.
Ternes, D., Karta, J., Tsenkova, M., Wilmes, P., Haan, S., & Letellier, E. (2020, February 13). Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism? Trends in Microbiology.
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2019

Greenhalgh, K., Ramiro Garcia, J., Heinken, Ullmann, P., Bintener, T. J. R., Pacheco, M., Baginska, J., Shah, P., Frachet Bour, A., Halder, R., Fritz, J., Sauter, T., Thiele, I., Haan, S., Letellier, E., & Wilmes, P. (2019). Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells. Cell Reports, 27, 1621–1632.
Nurmik, M., Ullmann, P., Rodriguez, F., Haan, S., & Letellier, E. (2019, February). In search of definitions: Cancer-associated fibroblasts and their markers. International Journal of Cancer.
Pacheco, M., Bintener, T. J. R., Ternes, D., Kulms, D., Haan, S., Letellier, E., & Sauter, T. (2019). Identifying and targeting cancer-specific metabolism with network-based drug target prediction. EBioMedicine, 43(May 2019), 98-106.
Qureshi-Baig, K., Kuhn, Viry, E., Pozdeev, V., Schmitz, M., Rodriguez, F., Ullmann, P., Koncina, E., Nurmik, M., Frasquilho, S., Nazarov, P. V., Zuegel, N., Boulmont, M., Karapetyan, Y., Antunes, L., Val, D., Mittelbronn, M., Janji, B., Haan, S., & Letellier, E. (2019, November 27). Hypoxia-induced Autophagy Drives Colorectal Cancer Initiation and Progression by Activating the PRKC/PKC-EZR (Ezrin) Pathway. Autophagy.
Ullmann, P., Nurmik, M., Begaj, R., Haan, S., & Letellier, E. (2019). Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells. Cells, 8(6).
Ullmann, P., Nurmik, M., Schmitz, M., Rodriguez, F., Weilerr, J., Baig, K., Felten, P., Nazarov, P., NICOT, N., Zuegel, N., Haan, S., & Letellier, E. (2019). Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity. Cancer Letters, 450, 32-41.
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2018

Greenhalgh, K., Ramiro Garcia, J., Heinken, A. K., Baginska, J., Letellier, E., Halder, R., Frachet Bour, A., Ullmann, P., Thiele, I., Haan, S., & Wilmes, P. (2018, February 16). Cominatorial effect of dietary fibre and Lactobacillus rhamnosus in the context of colorectal cancer therapy. Poster session presented at Cell Immunology symposium.
Rolvering, C., Zimmer, A. D., Ginolhac, A., Margue, C., Kirchmeyer, M., Servais, F., Hermanns, H. M., Hergovits, S., Nazarov, P. V., Nicot, N., Kreis, S., Haan, S., Behrmann, I., & Haan, C. (2018). The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies. Journal of Leukocyte Biology, 104, 969-985.
Ullmann, P., Rodriguez, F., Schmitz, M., Meurer, S. K., Qureshi-Baig, K., Felten, P., Ginolhac, A., Antunes, L., Frasquilho, S., Zugel, N., Weiskirchen, R., Haan, S., & Letellier, E. (2018). The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer research.
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2017

Bahlawane, C., Schmitz, M., Letellier, E., Arumugam, K., Nicot, N., Nazarov, P., & Haan, S. (2017, January 29). Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling. Cell Signal.
Baig, K., Ullmann, P., Haan, S., & Letellier, E. (2017, February 16). Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies. Molecular Cancer.
Greenhalgh, K., Fritz, J., Letellier, E., Ramiro Garcia, J., Halder, R., Frachet Bour, A., Baginska, J., Ternes, D., Jäger, C., Haan, S., & Wilmes, P. (2017). A study of the molecular mechanisms underlying teh response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics. Poster session presented at ISAPP conference.
Letellier, E., Schmitz, M., Ginolhac, A., Rodriguez, F., Ullmann, P., Qureshi-Baig, K., Frasquilho, S., Antunes, L., & Haan, S. (2017). Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence. British Journal of Cancer, 117(11), 1689-1701.
Rolvering, C., Zimmer, A., Kozar, I., Hermanns, Letellier, E., Vallar, L., Nazarov, P., Nicot, N., Ginolhac, A., Haan, S., Behrmann, I., & Haan, C. (2017, March). Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines. BBA Molecular Cell Research, 516-526.
Ternes, D., Wilmes, P., Letellier, E., & Haan, S. (2017, February 05). From meta-genomics to causality: Understanding the role of colon cancer-associated bacteria in colorectal cancer. Poster session presented at Keystone symposia: Microbiome in Health and Disease (J8), Keystone, Colorado, USA.
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2016

Bahlawane, C., Schmitz, M., Letellier, E., Arumugam, K., Nicot, N., Nazarov, P., & Haan, S. (2016, November). Data on quantification of signaling pathways activated by KIT and PDGFRA mutants. Data in Brief, (9), 828-838.
Baig, K., Ullmann, P., Rodriguez, F., Frasquilho, S., Nazarov, P. V., Haan, S., & Letellier, E. (2016). What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. PLoS ONE, 11.
Greenhalgh, K., Fritz, J., Letellier, E., Frachet Bour, A., Baginska, J., Shah, P., Desai, M., Glaab, E., Jäger, C., Haan, S., & Wilmes, P. (2016, June). A study of the molecular mechanisms underlying the response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics. Poster session presented at ISAPP conference, Turku, Finland.
Letellier, E., & Haan, S. (2016). SOCS2: physiological and pathological functions. Frontiers in Bioscience (Elite Edition), 8, 189-204.
Martincuks, A., Fahrenkamp, D., Haan, S., Herrmann, A., Küster, A., & Müller-Newen, G. (2016). Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3. Cellular Signalling, 28(8), 810-25.
Trairatphisan, P., Wiesinger, M., Bahlawane, C., Haan, S., & Sauter, T. (2016). A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST. PloS one, 11(5), 0156223.
Ullmann, P., qureshi-baig, K., Rodriguez, F., Ginolhac, A., nonnenmacher, Y., Ternes, D., Weiler, J., Gaebler, K., bahlawane, C., hiller, K., Haan, S., & Letellier, E. (2016). Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production. Oncotarget, 7(40), 97-114.
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2015

Bahlawane, C., Eulenfeld, R., Wiesinger, M., Wang, J., Muller, A., Girod, A., Nazarov, P. V., Felsch, K., Vallar, L., Sauter, T., Satagopam, V., & Haan, S. (2015). Constitutive activation of oncogenic PDGFRalpha-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRalpha signalling characteristics. Cell Communication and Signaling, 13, 21.
Haan, S., Bahlawane, C., Wang, J., Nazarov, P. V., Muller, A., Eulenfeld, R., Haan, C., Rolvering, C., Vallar, L., Satagopam, V., Sauter, T., & Wiesinger, M. (2015). The oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart. JAK-STAT, 4(1), 1062596.
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2014

Heinrich, P. C., Haan, S., Hermanns, H. M., Müller-Newen, G., & Schaper, F. (2014). Kapitel 34: Mediatoren. In P. C., Heinrich, M., Müller, & L., Graeve (Eds.), Biochemie und Pathobiochemie (9th edition, pp. 407-410). Berlin, Germany: Springer.
Heinrich, P. C., Haan, S., Hermanns, H. M., Müller-Newen, G., & Schaper, F. (2014). Kapitel 35: Rezeptoren und ihre Signaltransduktion. In P. C., Heinrich, M., Müller, & L., Graeve (Eds.), Biochemie und Pathobiochemie (9th edition, pp. 411-441). Berlin, Germany: Springer.
Letellier, E., Schmitz, M., Baig, K., Beaume, N., Schwartz, C., Frasquilho, S., Antunes, L., Marcon, N., Nazarov, P. V., Vallar, L., Even, J., & Haan, S. (2014). Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer. British journal of cancer, 111(4), 726-35.
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2013

Haan, C., & Haan, S. (2013). Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins. Methods in Molecular Biology, 967, 21-38.
Haan, S., & Haan, C. (2013). Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents. Methods in Molecular Biology, 967, 147-59.
Wolf, A., Eulenfeld, R., Gäbler, K., Rolvering, C., Haan, S., Behrmann, I., Denecke, B., Haan, C., & Schaper, F. (2013). JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells. JAK-STAT, 2(3), 24574.
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2012

Haan, C., Ungureanu, D., Pekkala, T., Silvennoinen, O., & Haan, S. (2012). Regulation of JAKs: Insights gleaned from the functional protein domains. In T., Decker & M., Müller (Eds.), JAK-STAT Signaling – From Basics to Disease (pp. 5-25). Wien, Austria: Springer-Verlag.
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2010

Haan, C., Behrmann, I., & Haan, S. (2010). Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases. Journal of Cellular and Molecular Medicine, 14(3), 504-27.
Schoenherr, C., Weiskirchen, R., & Haan, S. (2010). Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses. Cell Communication and Signaling, 8, 19.
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2009

Bender, H., Wiesinger, M., Nordhoff, C., Schoenherr, C., Haan, C., Ludwig, S., Weiskirchen, R., Kato, N., Heinrich, P. C., & Haan, S. (2009). Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes. Hepatology, 50(2), 585-91.
Haan, C., Kroy, D. C., Wüller, S., Sommer, U., Nöcker, T., Rolvering, C., Behrmann, I., Heinrich, P. C., & Haan, S. (2009). An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses. Journal of Immunology, 182(5), 2969-2977.
Haan, S., Wuller, S., Kaczor, J., Rolvering, C., Nocker, T., Behrmann, I., & Haan, C. (2009). SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling. Oncogene, 28(34), 3069-80.
Wiesinger, M., Haan, S., Wuller, S., Kauffmann, M.-E., Recker, T., Kuster, A., Heinrich, P. C., & Muller-Newen, G. (2009). Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1). Chemistry and Biology, 16(7), 783-94.
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2008

Haan, S., Margue, C., Engrand, A., Rolvering, C., Schmitz-Van de Leur, H., Heinrich, P. C., Behrmann, I., & Haan, C. (2008). Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation. Journal of Immunology, 180(2), 998-1007.
Kreis, S., Munz, G. A., Haan, S., Heinrich, P. C., & Behrmann, I. (2008). Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Molecular Cancer Research, 5(12), 1331-41.
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2005

Haan, S., Keller, J. F., Behrmann, I., Heinrich, P. C., & Haan, C. (2005). Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation. Cellular Signalling, 17(12), 1542-50.
Komyod, W., Bauer, U. M., Heinrich, P. C., Haan, S., & Behrmann, I. (2005). Are STATS arginine-methylated? Journal of Biological Chemistry, 280(23), 21700-5.
Radtke, S.* , Haan, S.* , Jörissen, A.* , Hermanns, H. M., Diefenbach, S., Smyczek, T., Schmitz-Vandeleur, H., Heinrich, P. C., Behrmann, I., & Haan, C. (2005). The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression. Journal of Biological Chemistry, 280(27), 25760-8.
* These authors have contributed equally to this work.
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2004

Behrmann, I., Smyczek, T., Heinrich, P. C., Schmitz-Van de Leur, H., Komyod, W., Giese, B., Muller-Newen, G., Haan, S., & Haan, C. (2004). Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase. Journal of Biological Chemistry, 279(34), 35486-93.
Fischer, P., Lehmann, U., Sobota, R. M., Schmitz, J., Niemand, C., Linnemann, S., Haan, S., Behrmann, I., Yoshimura, A., Johnston, J. A., Müller-Newen, G., Heinrich, P. C., & Schaper, F. (2004). The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling. Biochemical Journal, 378(Pt 2), 449-60.
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