Prof. Dr. Stephanie Kreis

Stephanie Kreis

Associate professor/Chief scientist 2

Faculté ou Centre Faculté des Sciences, des Technologies et de Médecine
Department Département Sciences de la vie et médecine
Adresse postale Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Bureau sur le campus BioTech II Ketterthill, 4.18
Téléphone (+352) 46 66 44 6884
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See detailCross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells
Kozar, Ines; Philippidou, Demetra; Margue, Christiane; Gay, Lauren; Renne, Rolf; Kreis, Stephanie

in Cancers (2021)

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See detailNRAS mutant melanoma: Towards better therapies
Randic, Tijana; Kozar, Ines; Margue, Christiane; Utikal, Jochen; Kreis, Stephanie

in Cancer Treatment Reviews (2021), 99

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See detailSystematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types
Kirchmeyer, Mélanie; Servais, Florence; Ginolhac, Aurélien; Nazarov, Petr V.; Margue, Christiane; Philippidou, Demetra; Nicot, Nathalie; Behrmann, Iris; Haan, Claude; Kreis, Stephanie

in Journal of Molecular Biology (2020)

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See detailHypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles
Walbrecq, Geoffroy; Lecha, Odile; Gaigneaux, Anthoula; Fougeras, Miriam R .; Philippidou, Demetra; Margue, Christiane; Tetsi Nomigni, Milène; Bernardin, François; Dittmar, Gunnar; Behrmann, Iris; Kreis, Stephanie

in Cancers (2020)

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See detailDistinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells
Walbrecq, Geoffroy; Margue, Christiane; Behrmann, Iris; Kreis, Stephanie

in International Journal of Molecular Sciences (2020)

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See detailMany ways to resistance: How melanoma cells evade targeted therapies
Kozar, Ines; Margue, Christiane; Rothengatter, Sonja; Haan, Claude; Kreis, Stephanie

in Biochimica et Biophysica Acta - Reviews on Cancer (2019), 1871(2), 313-322

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See detailKinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells
Margue, Christiane; Philippidou, Demetra; Kozar, Ines; Cesi, Giulia; Felten, Paul; Kulms, Dagmar; Letellier, Elisabeth; Haan, Claude; Kreis, Stephanie

in Journal of Experimental and Clinical Cancer Research (2019), 38(1),

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See detailDeconvolution of Transcriptomes and miRNomes by Independent Component Analysis Provides Insights Into Biological Processes and Clinical Outcomes of Melanoma Patients
Nazarov, Petr V.; Wienecke-Baldacchino, Anke K.; Zinovyev, Andrei; Czerwińska, Urszula; Muller, Arnaud; Nashan, Dorothée; Dittmar, Gunnar; Azuaje, Francisco; Kreis, Stephanie

in BMC Medical Genomics (2019), 12 (1)(132),

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See detailModulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Minoungou, Wendkouni Nadège; Rose-John, Stefan; Kreis, Stephanie; Haan, Claude; Behrmann, Iris

in Molecular Therapy: Nucleic Acids (2019), 16

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See detailTranscriptional variations in the wider peritumoral tissue environment of pancreatic cancer
Bauer, Andrea S.; Nazarov, Petr V.; Giese, Nathalia A.; Beghelli, Stefania; Heller, Anette; Greenhalf, William; Costello, Eithne; Muller, Arnaud; Bier, Melanie; Strobel, Oliver; Hackert, Thilo; Vallar, Laurent; Scarpa, Aldo; Büchler, Markus W.; Neoptolemos, John P.; Kreis, Stephanie; Hoheisel, Jorg D.

in International Journal of Cancer (2018), 142(5), 10101021

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See detailA new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells
Cesi, Giulia; Philippidou, Demetra; Kozar, Ines; Kim, Y. J.; Bernardin, F.; Van Niel, G.; Wienecke-Baldacchino, A.; Felten, Paul; Letellier, Elisabeth; Dengler, S.; Nashan, D.; Haan, Claude; Kreis, Stephanie

in Molecular Cancer (2018), (17:145),

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See detailCytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Kirchmeyer, Melanie; Servais, Florence; Hamdorf, Matthias; Nazarov, Petr V.; Ginolhac, Aurélien; Halder, Rashi; Vallar, Laurent; Glanemann, Matthias; Rubie, Claudia; Lammert, Frank; Kreis, Stephanie; Behrmann, Iris

in Journal of leukocyte biology (2018)

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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See detailROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells
Cesi, Giulia; Walbrecq, Geoffroy; Zimmer, Andreas David; Kreis, Stephanie; Haan, Claude

in Molecular Cancer (2017), 8(june),

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See detailImpact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells
Kreis, Stephanie; Kozar, Ines; Cesi, Giulia; Margue, Christiane; Philippidou, Demetra

in Biochimica et Biophysica Acta (2017)

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See detailTargeting autophagy inhibits growth by enhancing NK cells infiltration in a CCL5-dependent manner
Mgrditchian, T; Arakelian, T; Paggetti, J; Noman, MZ; Viry, E; Moussay, E; Van Moer, K; Kreis, Stephanie; Guerin, C; Buart, S; Robert, C; Borg, C; Vielh, P; Chouaib, S; Berchem, G; Janji, B

in Proceedings of the National Academy of Sciences of the United States of America (2017), 114((44)), 9271-9279

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See detailTransferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons"
Cesi, Giulia; Walbrecq, Geoffroy; Margue, Christiane; Kreis, Stephanie

in Cell Communication and Signaling (2016), 14(1), 13

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See detailThe TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner
Heulot, Mathieu; Chevalier, Nadja; Puyal, Julien; Margue, Christiane; Michel, Sébastien; Kreis, Stephanie; Kulms, Dagmar; Barras, David; Nahimana, Aimable; Widmann, Christian

in Oncotarget (2016), 7(39),

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See detailmiRNAs in ancient tissue specimens of the Tyrolean Iceman
Keller, Andreas; Kreis, Stephanie; Leidinger, Petra; Maixner, Frank; Ludwig, Nicole; Backes, Christina; Galata, Valentina; Guerriero, Gea; Fehlmann, Tobias; Franke, Andre; Meder, Benjamin; Zink, Albert; Meese, Eckart

in Molecular Biology and Evolution (2016), 34(4), 793-801

See detail“Melanomics”: analysis and integration of whole genomes, transcriptomes and miRNomes of primary melanoma patients
Reinsbach, Susanne; Wienecke, Anke; Ginolhac, Aurélien; Vallar, Laurent; Krishna; Krishna, Abhimanyu; Nazarov, Petr; May, Patrick; Kreis, Stephanie

in European Journal of Cancer (2016), 61(Suppl.1), 32

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See detailCirculating microRNAs as candidate biomarkers for the surveillance of melanoma patients
Behrmann, Iris; Margue, Christiane; Kreis, Stephanie

in EBioMedicine (2015)

See detailDynamic change of host gastrointestinal microbiome and immune status in relation to mucosal barrier effects during chemotherapy and immune ablative intervention in humans.
Kaysen, Anne; Buschart, Anna; May, Patrick; Laczny, Cedric Christian; Narayanasamy, Shaman; Graf, N; Simon, A; Bittenbring, J; Kreis, Stephanie; Schneider, Jochen; Wilmes, Paul

Poster (2015, June)

See detailChanges in the human gastrointestinal microbiome during cancer treatments
Kaysen, Anne; Heintz, Anna; Lebrun, Laura; Graf, N; Simon, A; Bittenbring, J; Kreis, Stephanie; Schneider, Jochen; Wilmes, Paul

Poster (2015, March)

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See detailComparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?
Margue, Christiane; Reinsbach, Susanne; Philippidou, Demetra; Beaume, Nicolas; Walters, Casandra; Schneider, Jochen; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Oncotarget (2015), 6(14), 12110-27

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See detailID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Haan, Claude; Casper, Markus; Lammert, Frank; Nazarov, Petr; Vallar, Laurent; Kreis, Stephanie; Behrmann, Iris

in Cytokine (2015), 76(1), 99-

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See detailDynamic change of host gastrointestinal microbiome and immune status in relation to mucosal barrier effects during chemotherapy and immune ablative intervention in humans
Kaysen, Anne; Heintz, Anna; Lebrun, Laura; Graf, Norbert; Simon, Arne; Bittenbring, Jörg; Kreis, Stephanie; Schneider, Jochen; Wilmes, Paul

Poster (2014, April)

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See detailNew Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion
Margue, Christiane; Philippidou, Demetra; Reinsbach, Susanne; Schmitt, Martina; Behrmann, Iris; Kreis, Stephanie

in PLoS ONE (2013), 8(9),

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See detailInterplay of microRNAs, transcription factors and target genes: Linking dynamic expression changes to function
Nazarov, P. V. A; Reinsbach, Susanne; Muller, A. A; Nicot, N. A; Philippidou, Demetra; Vallar, L. A; Kreis, Stephanie

in Nucleic Acids Research (2013), 41(5), 2817-2831

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See detailDynamic regulation of microRNA expression following interferonγ- induced gene transcription
Reinsbach, Susanne; Nazarov, Petr V.; Philippidou, Demetra; Schmitt, Martina; Wienecke, Anke; Muller, Arnaud; Vallar, Laurent; Behrmann, Iris; Kreis, Stephanie

in RNA Biology (2012), 9(7), 987-989

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See detailInterferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells
Schmitt, Martina J.; Philippidou, Demetra; Reinsbach, Susanne; Margue, Christiane; Wienecke-Baldacchino, Anke; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Cell Communication and Signaling (2012), 10

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See detailMiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties
Schmitt, Martina; Margue, Christiane; Behrmann, Iris; Kreis, Stephanie

in Current Molecular Medicine (2012), 13(4), 572-585

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See detailIL-24: Physiological and supraphysiological effects on normal and malignant cells
Margue, Christiane; Kreis, Stephanie

in Current Medicinal Chemistry (2010), 17(29), 3318-3326

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See detailSignatures of MicroRNAs and selected MicroRNA target genes in human melanoma
Philippidou, Demetra; Schmitt, Martina; Moser, Dirk; Margue, Christiane; Nazarov, Petr V.; Muller, Arnaud; Vallar, Laurent; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Cancer Research (2010), 70(10), 4163-4173

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See detailCell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
Kreis, Stephanie; Munz, George. A.; Haan, Serge; Heinrich, Peter. C.; Behrmann, Iris

in Molecular Cancer Research (2008), 5(12), 1331-41

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See detailIL-24: a classic cytokine and/or a potential cure for cancer?
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Behrmann, Iris

in Journal of Cellular and Molecular Medicine (2008), 12(6A), 2505-2510

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See detailRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Rolvering, Catherine; Haan, Claude; Dumoutier, Laure; Renauld, Jean-Christophe; Behrmann, Iris

in PLoS ONE (2007), 2(12), 1300

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See detailJaks and cytokine receptors - an intimate relationship
Haan, Claude; Kreis, Stephanie; Margue, Christiane; Behrmann, Iris

in Biochemical Pharmacology (2006), 72(11), 1538-46

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See detailThe intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions
Kreis, Stephanie; Schönfeld, H.-J. B; Melchior, C. A; Steiner, B. B C; Kieffer, N. A

in Experimental Cell Research (2005), 305(1), 110-121

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See detailA fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain
Tremuth, Laurent A; Kreis, Stephanie; Melchior, Chantal; Hoebeke, Johan; Rondé, Philippe; Plançon, Sébastien; Takeda, Kenneth; Kieffer, Nelly

in Journal of Biological Chemistry (2004), 279(21), 22258-22266

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See detailPromoter characterization and genomic organization of the gene encoding integrin-linked kinase 1
Melchior, C. A; Kreis, Stephanie; Janji, B. B; Kieffer, N. A

in Biochimica et Biophysica Acta-Gene Structure and Expression (2002), 1575(1-3), 117-122

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See detailPlacental transfer and decay of maternally acquired antimeasles antibodies in Nigerian children
Hartter, H. K.; Oyedele, O. I.; Dietz, K.; Kreis, Stephanie; Hoffman, J. P.; Muller, Claude

in Pediatric Infectious Disease Journal (2000), 19(7), 635-641

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See detailGenotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates
Truong, A. T.; Kreis, Stephanie; Ammerlaan, W.; Hartter, H. K.; Adu, F.; Omilabu, S. A.; Oyefolu, A. O.; Berbers, G. A. M.; Muller, Claude

in Virus Research (1999), 62(1), 89-95

See detailIsolation of measles virus from a naturally-immune, asymptomatically re-infected individual
Vardas, E. A B; Kreis, Stephanie

in Journal of Clinical Virology (1999), 13(3), 173-179

See detailCase report and molecular analysis of subacute sclerosing panencephalitis in a South African child
Vardas, E. A D; Leary, P. M. B; Yeats, J. C; Badrodien, W. B; Kreis, Stephanie

in Journal of Clinical Microbiology (1999), 37(3), 775-777

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See detailSequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype
Kreis, Stephanie; Vardas, E.; Whistler, T.

in Journal of General Virology (1997), 78(7), 1581-1587

See detailRapid identification of measles virus strains by the heteroduplex mobility assay
Kreis, Stephanie; Whistler, T.

in Virus Research (1997), 47(2), 472197-203

See detailMeasles virus transmission from infected to immune individuals - Implications for measles control and elimination
Vardas, E.; Andre, M.; Kreis, Stephanie; Zachariades, N.; Schoub, B.

in South African Medical Journal (1997), 87(12), 1709

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