Iris Behrmann

Iris Behrmann

Full professor en Biochimie

Sujets de recherche Biochemistry, Cytokine Signal Transduction
Faculté ou Centre Faculté des Sciences, des Technologies et de Médecine
Adresse postale Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Bureau sur le campus BioTech II, 4.26
E-mail
Téléphone (+352) 46 66 44 6740

Position

Last updated on: mardi 22 octobre 2019

Academic Qualifications

  • Diploma in Biology, Universität Bielefeld, Germany, 1990
  • PhD (Dr. rer. nat.), Universität Bielefeld, Germany, 1992 (thesis at the German Cancer Research Center, Heidelberg)
  • Habilitation, venia legendi in Biochemistry, RWTH-Aachen Medical School, Germany, 2001



Last updated on: 29 jan 2010

Research Interests

  • molecular mechanisms of cytokine signal transduction,
  • (patho)physiologic consequences of Jak/STAT signalling, e. g. the role of constitutively active Jak mutants in myeloproliferative neoplasms,
  • microRNAs in melanoma development and growth regulation,
  • cross-talk of cytokine signal transduction with other signalling pathways (hypoxia, growth factors).



Last updated on: 29 jan 2010

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2019

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See detailmiR-873-5p targets mitochondrialGNMT-Complex II interface contributing tonon-alcoholic fatty liver disease
Fernández-Tussy, Pablo; Fernández-Ramos, David; Lopitz-Otsoa, Fernando; Simón, Jorge; Barbier-Torres, Lucía; Gomez-Santos, Beatriz; Nuñez-Garcia, Maitane; Azkargorta, Mikel; Gutiérrez-de Juan, Virginia; Serrano-Macia, Marina; Rodríguez-Agudo, Rubén; Iruzubieta, Paula; Anguita, Juan; Castro, Rui Eduardo; Champagne, Devin; Rincón, Mercedes; Elortza, Felix; Arslanow, Anita; Krawczyk, Marcin; Lammert, Frank; Kirchmeyer, Mélanie; Behrmann, Iris; Crespo, Javier; Lu, Shelly; Mato, José; Varela-Rey, Marta; Aspichueta, Patricia; Cardoso Delgado, Teresa; Martinez_Chantar, Maria

in Molecular Metabolism (2019)

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See detailModulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Minoungou, Wendkouni Nadège; Rose-John, Stefan; Kreis, Stephanie; Haan, Claude; Behrmann, Iris

in Molecular Therapy: Nucleic Acids (2019), 16

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2018

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See detailCytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Kirchmeyer, Melanie; Servais, Florence; Hamdorf, Matthias; Nazarov, Petr V.; Ginolhac, Aurélien; Halder, Rashi; Vallar, Laurent; Glanemann, Matthias; Rubie, Claudia; Lammert, Frank; Kreis, Stephanie; Behrmann, Iris

in Journal of leukocyte biology (2018)

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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2017

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See detailThe multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells
Bongartz, Hannes; Hessenkemper, Wiebke; Müller, Christian; Fensky, Melissa; Fritsch, Johannes; Mandel, Katharina; Behrmann, Iris; Haan, Claude; Fischer, Thomas; Feller, Stephan M.; Schaper, Fred

in Cellular Signalling (2017), 35

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See detailCrosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
Rolvering, Catherine; Zimmer, Andreas; Kozar, Ines; Hermanns; Letellier, Elisabeth; Vallar, Laurent; Nazarov, Petr; Nicot, Nathalie; Ginolhac, Aurélien; Haan, Serge; Behrmann, Iris; Haan, Claude

in BBA Molecular Cell Research (2017)

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2016

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See detailThe role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.
Battello, Nadia; Zimmer, Andreas David; Goebel, Carole; Dong, Xiangyi; Behrmann, Iris; Haan, Claude; Hiller, Karsten; Wegner, Andre

in Cancer & metabolism (2016), 4

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See detailVariant PNPLA3 increases the HCC risk: prospective study in patients treated at the Saarland University Medical Center
Casper, Markus; Krawczyk, Marcin; Behrmann, Iris; Glanemann, Matthias; Lammert, Frank

in Zeitschrift für Gastroenterologie (2016), 54

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See detailPhosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
Zimmer, Andreas David; Walbrecq, Geoffroy; Kozar, Ines; Behrmann, Iris; Haan, Claude

in Hypoxia (2016), 4

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2015

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See detailCirculating microRNAs as candidate biomarkers for the surveillance of melanoma patients
Behrmann, Iris; Margue, Christiane; Kreis, Stephanie

in EBioMedicine (2015)

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See detailComparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?
Margue, Christiane; Reinsbach, Susanne; Philippidou, Demetra; Beaume, Nicolas; Walters, Casandra; Schneider, Jochen; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Oncotarget (2015), 6(14), 12110-27

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See detailID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Haan, Claude; Casper, Markus; Lammert, Frank; Nazarov, Petr; Vallar, Laurent; Kreis, Stephanie; Behrmann, Iris

in Cytokine (2015), 76(1), 99-

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2013

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See detailJAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Gäbler, Karoline; Behrmann, Iris; Haan, Claude

in JAK-STAT (2013), 2(3), 25025

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See detailCooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F
Gäbler, Karoline; Rolvering, Catherine; Kaczor, Jakub; Eulenfeld, R.; Méndez, S. A.; Berchem, G.; Palissot, V.; Behrmann, Iris; Haan, Claude

in Journal of Cellular & Molecular Medicine (2013), 17(2), 265-276

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See detailNew Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion
Margue, Christiane; Philippidou, Demetra; Reinsbach, Susanne; Schmitt, Martina; Behrmann, Iris; Kreis, Stephanie

in PLoS ONE (2013), 8(9),

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See detailJAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.
Wolf, Alexandra; Eulenfeld, Rene; Gäbler, Karoline; Rolvering, Catherine; Haan, Serge; Behrmann, Iris; Denecke, Bernd; Haan, Claude; Schaper, Fred

in JAK-STAT (2013), 2(3), 24574

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2012

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See detailDynamic regulation of microRNA expression following interferonγ- induced gene transcription
Reinsbach, Susanne; Nazarov, Petr V.; Philippidou, Demetra; Schmitt, Martina; Wienecke, Anke; Muller, Arnaud; Vallar, Laurent; Behrmann, Iris; Kreis, Stephanie

in RNA Biology (2012), 9(7), 987-989

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See detailInterferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells
Schmitt, Martina J.; Philippidou, Demetra; Reinsbach, Susanne; Margue, Christiane; Wienecke-Baldacchino, Anke; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Cell Communication and Signaling (2012), 10

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See detailMiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties
Schmitt, Martina; Margue, Christiane; Behrmann, Iris; Kreis, Stephanie

in Current Molecular Medicine (2012), 13(4), 572-585

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2011

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See detailJak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors
Haan, Claude; Rolvering, Catherine; Raulf, F.; Kapp, M.; Drückes, P.; Thoma, G.; Behrmann, Iris; Zerwes, H.-G.

in Chemistry & Biology (2011), 18(3), 314-323

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2010

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See detailSignal transduction, receptors, mediators and genes: Younger than ever - The 13th meeting of the Signal Transduction Society focused on aging and immunology
Entschladen, F.; Altschmied, J.; Baumgrass, R.; Behrmann, Iris; Giehl, K.; Hermanns, H.; Huber, O.; Kieser, A.; Klotz, L.-O.; Kubatzky, K. F.; Hass, R.; Janssen, O.; Friedrich, K.

in Cell Communication and Signaling (2010), 8

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See detailPerspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan, Claude; Behrmann, Iris; Haan, Serge

in Journal of Cellular & Molecular Medicine (2010), 14(3), 504-27

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See detailSignatures of MicroRNAs and selected MicroRNA target genes in human melanoma
Philippidou, Demetra; Schmitt, Martina; Moser, Dirk; Margue, Christiane; Nazarov, Petr V.; Muller, Arnaud; Vallar, Laurent; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Cancer Research (2010), 70(10), 4163-4173

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See detailCross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation
Radtke, S.; Wüller, S.; Yang, X.-P.; Lippok, B. E.; Mütze, B.; Mais, C.; Schmitz-Van De Leur, H.; Bode, J. G.; Gaestel, M.; Heinrich, P. C.; Behrmann, Iris; Schaper, F. A; Hermanns, H. M.

in Journal of Cell Science (2010), 123(6), 947-959

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See detailOncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells
Vollmer, Stefan; Haan, Claude; Behrmann, Iris

in Biochemical Pharmacology (2010), 80(12), 2066-2073

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2009

See detailZelluläre Signalprozesse
Friedrich, Karlheinz; Behrmann, Iris

in Biochemie und Molekularbiologie des Menschen (2009)

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See detailAn unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
Haan, Claude; Kroy, Daniela C.; Wüller, Stefan; Sommer, Ulrike; Nöcker, Tanja; Rolvering, Catherine; Behrmann, Iris; Heinrich, Peter C.; Haan, Serge

in Journal of Immunology (2009), 182(5), 2969-2977

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See detailSOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Haan, Serge; Wuller, S.; Kaczor, Jakub; Rolvering, Catherine; Nocker, T.; Behrmann, Iris; Haan, Claude

in Oncogene (2009), 28(34), 3069-80

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See detailHypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling
Vollmer, Stefan; Kappler, Valérie; Kaczor, Jakub; Flügel, Daniela; Rolvering, Catherine; Kato, Nobuyuki; Kietzmann, Thomas; Behrmann, Iris; Haan, Claude

in Hepatology (Baltimore, Md.) (2009), 2009(3),

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2008

See detailDual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
Haan, Serge; Margue, Christiane; Engrand, A.; Rolvering, Catherine; Schmitz-Van de Leur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Immunology (2008), 180(2), 998-1007

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See detailCell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
Kreis, Stephanie; Munz, George. A.; Haan, Serge; Heinrich, Peter. C.; Behrmann, Iris

in Molecular Cancer Research (2008), 5(12), 1331-41

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See detailIL-24: a classic cytokine and/or a potential cure for cancer?
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Behrmann, Iris

in Journal of Cellular & Molecular Medicine (2008), 12(6A), 2505-2510

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2007

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See detailA cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background
Haan, Claude; Behrmann, Iris

in Journal of Immunological Methods (2007), 318(1-2), 11-9

See detailConstitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line
Komyod, W.; Böhm, M.; Metze, D.; Heinrich, P. C.; Behrmann, Iris

in Molecular Cancer Research (2007), 5(3), 271-81

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See detailRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Rolvering, Catherine; Haan, Claude; Dumoutier, Laure; Renauld, Jean-Christophe; Behrmann, Iris

in PLoS ONE (2007), 2(12), 1300

See detailSTAT1 regulates p73-mediated Bax gene expression
Soond, S. M.; Carroll, C.; Townsend, P. A.; Sayan, E.; Melino, G.; Behrmann, Iris; Knight, R. A.; Latchman, D. S.; Stephanou, A.

in FEBS Letters (2007), 581(6), 1217-26

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2006

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See detailJaks and cytokine receptors - an intimate relationship
Haan, Claude; Kreis, Stephanie; Margue, Christiane; Behrmann, Iris

in Biochemical Pharmacology (2006), 72(11), 1538-46

See detailThree dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase
Radtke, S.; Jörissen, A.; de Leur, H. S.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2006), 281(7), 4024-34

See detailBiological responses to PDGF-BB versus PDGF-DD in human mesangial cells
van Roeyen, C. R.; Ostendorf, T.; Denecke, B.; Bokemeyer, D.; Behrmann, Iris; Strutz, F.; Lichenstein, H. S.; LaRochelle, W. J.; Pena, C. E.; Chaudhuri, A.; Floege, J.

in Kidney International (2006), 69(8), 1393-402

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2005

See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge; Keller, J. F.; Behrmann, Iris; Heinrich, P. C.; Haan, Claude

in Cellular Signalling (2005), 17(12), 1542-50

See detailPromoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma
Hellerbrand, C.; Mühlbauer, M.; Wallner, S.; Schuierer, M.; Behrmann, Iris; Bataille, F.; Weiss, T.; Schölmerich, J.; Bosserhoff, A. K.

in Carcinogenesis (2005), 27(1), 64-72

See detailAre STATS arginine-methylated?
Komyod, W.; Bauer, U. M.; Heinrich, P. C.; Haan, Serge; Behrmann, Iris

in Journal of Biological Chemistry (2005), 280(23), 21700-5

See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge; Jörissen, A.; Hermanns, H. M.; Diefenbach, S.; Smyczek, T.; Schmitz-Vandeleur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Biological Chemistry (2005), 280(27), 25760-8

See detailSTAT5 contributes to interferon resistance of melanoma cells
Wellbrock, C.; Weisser, C.; Hassel, J. C.; Fischer, P.; Becker, J.; Vetter, C. S.; Behrmann, Iris; Kortylewski, M.; Heinrich, P. C.; Schartl, M.

in Current Biology (2005), 15(18), 1629-39

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2004

See detailJanus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase
Behrmann, Iris; Smyczek, Tanja; Heinrich, Peter C.; Schmitz-Van de Leur, Hildegard; Komyod, Waraporn; Giese, Bernd; Muller-Newen, Gerhard; Haan, Serge; Haan, Claude

in Journal of Biological Chemistry (2004), 279(34), 35486-93

See detailThe role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
Fischer, P.; Lehmann, U.; Sobota, R. M.; Schmitz, J.; Niemand, C.; Linnemann, S.; Haan, Serge; Behrmann, Iris; Yoshimura, A.; Johnston, J. A.; Müller-Newen, G.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2004), 378(Pt 2), 449-60

See detailInterferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals
Kortylewski, M.; Komyod, W.; Kauffmann, M. E.; Bosserhoff, A. K.; Heinrich, P. C.; Behrmann, Iris

in Journal of Investigative Dermatology (2004), 122(2), 414-22

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2003

See detailCharacterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma
Behrmann, Iris; Wallner, S.; Komyod, W.; Heinrich, P. C.; Schuierer, M.; Buettner, R.; Bosserhoff, A. K.

in American Journal of Pathology (2003), 163(2), 683-90

See detailLong term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis
Giese, B.; Au-Yeung, C. K.; Herrmann, A.; Diefenbach, S.; Haan, Claude; Küster, A.; Wortmann, S. B.; Roderburg, C.; Heinrich, P. C.; Behrmann, Iris; Müller-Newen, G.

in Journal of Biological Chemistry (2003), 278(40), 39205-13

See detailPrinciples of interleukin (IL)-6-type cytokine signalling and its regulation
Heinrich, P. C.; Behrmann, Iris; Haan, Serge; Hermanns, H. M.; Müller-Newen, G.; Schaper, F.

in Biochemical Journal (2003), 374(Pt 1), 1-20

See detailAkt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism
Kortylewski, M.; Feld, F.; Krüger, K. D.; Bahrenberg, G.; Roth, R. A.; Joost, H. G.; Heinrich, P. C.; Behrmann, Iris; Barthel, A.

in Journal of Biological Chemistry (2003), 278(7), 5242-9

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2002

See detailIdentification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
Bahrenberg, G.; Behrmann, Iris; Barthel, A.; Hekerman, P.; Heinrich, P. C.; Joost, H. G.; Becker, Werner

in Molecular Endocrinology (2002), 16(4), 859-72

See detailOrientational constraints of the gp130 intracellular juxtamembrane domain for signaling
Greiser, J. S.; Stross, C.; Heinrich, P. C.; Behrmann, Iris; Hermanns, H. M.

in Journal of Biological Chemistry (2002), 277(30), 26959-65

See detailSHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
Lehmann, U.; Schmitz, J.; Weissenbach, M.; Sobota, R. M.; Hortner, M.; Friederichs, K.; Behrmann, Iris; Tsiaris, W.; Sasaki, A.; Schneider-Mergener, J.; Yoshimura, A.; Neel, B. G.; Heinrich, P. C.; Schaper, F.

in Journal of Biological Chemistry (2002), 278(1), 661-71

See detailNovel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
Radtke, S.; Hermanns, H. M.; Haan, Claude; Schmitz-Van De Leur, H.; Gascan, H.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2002), 277(13), 11297-305

See detailThe matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist
Roeb, E.; Schleinkofer, K.; Kernebeck, T.; Pötsch, S.; Jansen, B.; Behrmann, Iris; Matern, S.; Grötzinger, J.

in Journal of Biological Chemistry (2002), 277(52), 50326-32

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2001

See detailInterleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity
Böhm, M.; Schulte, U.; Funk, J. O.; Raghunath, M.; Behrmann, Iris; Kortylewski, M.; Heinrich, P. C.; Kues, T.; Luger, T. A.; Schwarz, T.

in Journal of Investigative Dermatology (2001), 117(1), 132-40

See detailMapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction
Haan, Claude; Isharc, H.; Hermanns, H. M.; Schmitz-Van De Leur, H.; Kerr, I. M.; Heinrich, P. C.; Grötzinger, J.; Behrmann, Iris

in Journal of Biological Chemistry (2001), 276(40), 37451-8

See detailNon-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor
Hermanns, H. M.; Radtke, S.; Schaper, F.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2001), 275(52), 40742-8

See detailA region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130
Hilkens, C. M.; Isharc, H.; Lillemeier, B. F.; Strobl, B.; Bates, P. A.; Behrmann, Iris; Kerr, I. M.

in FEBS Letters (2001), 505(1), 87-91

See detailMitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells
Kortylewski, M.; Heinrich, P. C.; Kauffmann, M. E.; Böhm, M.; MacKiewicz, A.; Behrmann, Iris

in Biochemical Journal (2001), 357(Pt 1), 297-303

See detailCytokine-mediated growth inhibition of human melanoma cells
Kortylewski, M.; Heinrich, P. C.; Mackiewicz, A.; Behrmann, Iris

in Advances in Experimental Medicine and Biology (2001), 495

See detailSTAT3 is constitutively activated in Hodgkin cell lines
Kube, D.; Holtick, U.; Vockerodt, M.; Ahmadi, T.; Haier, B.; Behrmann, Iris; Heinrich, P. C.; Diehl, V.; Tesch, H.

in Blood (2001), 98(3), 762-70

See detailA completely foreign receptor can mediate an interferon-gamma-like response
Strobl, B.; Arulampalam, V.; Isharc, H.; Newman, S. J.; Schlaak, J. F.; Watling, D.; Costa-Pereira, A. P.; Schaper, F.; Behrmann, Iris; Sheehan, K. C.; Schreiber, R. D.; Horn, F.; Heinrich, P. C.; Kerr, I. M.

in EMBO Journal (2001), 20(19), 5431-42

See detailNeutralizing monoclonal antibodies can potentiate IL-5 signaling
Zabeau, L.; Van der Heyden, J.; Broekaert, D.; Verhee, A.; Vandekerckhove, J.; Wu, S. J.; Chaiken, I.; Heinrich, P.; Behrmann, Iris; Tavernier, J.

in European Journal of Immunology (2001), 31(4), 1087-97

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2000

See detailSignal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation
Anhuf, D.; Weissenbach, M.; Schmitz, J.; Sobota, R.; Hermanns, H. M.; Radtke, S.; Linnemann, S.; Behrmann, Iris; Heinrich, P. C.; Schaper, F.

in Journal of Immunology (2000), 165(5), 2535-43

See detailSignalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor
Behrmann, Iris; Hermanns, H. M.; Haan, Claude; Kortylewski, M.; Radtke, S.; Greiser, J. S.; Heinrich, P. C.

in European Cytokine Network (2000), 11(3), 491-2

See detailCytoplasmic STAT proteins associate prior to activation
Haan, Serge; Kortylewski, M.; Behrmann, Iris; Müller-Esterl, W.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2000), 345 Pt 3

See detailContributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130
Hermanns, H. M.; Radtke, S.; Haan, Claude; Schmitz-Van de Leur, H.; Tavernier, J.; Heinrich, P. C.; Behrmann, Iris

in Journal of Immunology (2000), 163(12), 6651-8

See detailAn MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist
Roeb, E.; Behrmann, Iris; Grötzinger, J.; Breuer, B.; Matern, S.

in FASEB Journal (2000), 14(12), 1671-3

See detailDifferential inhibition of IL-6-type cytokine-induced STAT activation by PMA
Terstegen, L.; Maassen, B. G.; Radtke, S.; Behrmann, Iris; Schaper, F.; Heinrich, P. C.; Graeve, L.; Gatsios, P.

in FEBS Letters (2000), 478(1-2), 100-4

See detailTermination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis
Thiel, S.; Sommer, U.; Kortylewski, M.; Haan, Claude; Behrmann, Iris; Heinrich, P. C.; Graeve, L.

in FEBS Letters (2000), 470(1), 15-9

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1999

See detailInterleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1
Kortylewski, M.; Heinrich, P. C.; Mackiewicz, A.; Schniertshauer, U.; Klingmüller, U.; Nakajima, K.; Hirano, T.; Horn, F.; Behrmann, Iris

in Oncogene (1999), 18(25), 3742-53

See detailIdentification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor
Thiel, S.; Behrmann, Iris; Timmermann, A.; Dahmen, H.; Müller-Newen, G.; Schaper, F.; Tavernier, J.; Pitard, V.; Heinrich, P. C.; Graeve, L.

in Biochemical Journal (1999), 339 (Pt 1)

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1998

See detailInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
Heinrich, P. C.; Behrmann, Iris; Müller-Newen, G.; Schaper, F.; Graeve, L.

in Biochemical Journal (1998), 334 (Pt 2)

See detailInternalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway
Thiel, S.; Behrmann, Iris; Dittrich, E.; Muys, L.; Tavernier, J.; Wijdenes, J.; Heinrich, P. C.; Graeve, L.

in Biochemical Journal (1998), 330 (Pt 1)

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1997

See detailA single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation
Behrmann, Iris; Janzen, C.; Gerhartz, C.; Schmitz-Van de Leur, H.; Hermanns, H.; Heesel, B.; Graeve, L.; Horn, F.; Tavernier, J.; Heinrich, P. C.

in Journal of Biological Chemistry (1997), 272(8), 5269-74

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1996

See detailCytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
Kischkel, F. C.; Hellbardt, S.; Behrmann, Iris; Germer, M.; Pawlita, M.; Krammer, P. H.; Peter, M. E.

in EMBO Journal (1996), 14(22), 5579-88

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1995

See detailStructure of the human APO-1 gene
Behrmann, Iris; Walczak, H.; Krammer, P. H.

in European Journal of Immunology (1995), 24(12), 3057-62

See detailAPO-I-mediated apoptosis in normal and malignant lymphocytes
Dhein, J.; Behrmann, Iris; Daniel, P. T.; Debatin, K. M.; Klas, C.; Möller, P.; Oehm, A.; Trauth, B. C.; Walczak, H.; Krammer, P. H.

in Biochemical Society Transactions (1995), 22(3), 598-600

See detailThe role of APO-1-mediated apoptosis in the immune system
Krammer, P. H.; Dhein, J.; Walczak, H.; Behrmann, Iris; Mariani, S.; Matiba, B.; Fath, M.; Daniel, P. T.; Knipping, E.; Westendorp, M. O.

in Immunological Reviews (1995), 142

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1994

See detailRegulation of apoptosis in the immune system
Krammer, P. H.; Behrmann, Iris; Daniel, P. T.; Dhein, J.; Debatin, K. M.

in Current Opinion in Immunology (1994), 6(2), 279-89

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1992

See detailPurification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen
Oehm, A.; Behrmann, Iris; Falk, W.; Pawlita, M.; Maier, G.; Klas, C.; Li-Weber, M.; Richards, S.; Dhein, J.; Trauth, B. C.

in Journal of Biological Chemistry (1992), 267(15), 10709-15

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1990

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