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Dr. Ganesh Manoharan
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| Faculté ou Centre | Faculté des Sciences, des Technologies et de Médecine | ||||
| Department | Département Sciences de la vie et médecine | ||||
| Adresse postale |
Campus Belval, Université du Luxembourg 7, Avenue des Hauts Fourneaux L-4362 Esch-sur-Alzette |
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| Bureau sur le campus | BioTech I, 3.05B | ||||
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| Téléphone | (+352) 46 66 44 6025 | ||||
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2021
A Pharmacophore Model for SARS-CoV-2 3CLpro Small Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors; ;
in Journal of Chemical Information and Modeling (2021), 61(8), 4082-4096
A covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness; ; ; ; ; ; ;
in Frontiers in Cell and Developmental Biology (2021)
2020
PDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ACS Omega (2020), 5(1), 832-842
2019
High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors; ; ; ;
in Analytical Biochemistry (2019), 572
2018
Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.; ; ; ;
in Bioorganic & medicinal chemistry (2018), 26(18), 5062-5068
2016
Bifunctional Ligands for Inhibition of Tight-Binding Protein–Protein Interactions; ; ; ; ; ; ; ; ;
in Bioconjugate Chemistry (2016), 27(8), 1900-1910
Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases; ;
in Biophysical Chemistry (2016), 211
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells; ; ; ; ; ; ; ; ; ; ; ;
in Oncotarget (2016), 7(28), 43220-43238
2015
PIM kinase-responsive microsecond-lifetime photoluminescent probes based on selenium-containing heteroaromatic tricycle; ; ; ; ;
in RSC Advances (2015)
FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases; ; ; ; ; ; ; ;
in Analytical Biochemistry (2015)
2014
Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases; ; ; ; ; ; ; ;
in Chemical Communications (2014)
2012
Active site analysis of cis-epoxysuccinate hydrolase from Nocardia tartaricans using homology modeling and site-directed mutagenesis; ; ;
in Applied Microbiology and Biotechnology (2012), 93(6), 23772386
