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Prof. Dr. Eric Tschirhart
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| Faculté ou Centre | Faculté des Sciences, des Technologies et de Médecine | ||||||||
| Department | Département Sciences de la vie et médecine | ||||||||
| Adresse postale |
Université du Luxembourg Maison du Nombre 6, Avenue de la Fonte L-4364 Esch-sur-Alzette |
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| Bureau sur le campus | MNO, E05 0525-070 | ||||||||
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| Téléphone | (+352) 46 66 44 6100 | ||||||||
| Fax | (+352) 46 66 44 6105 | ||||||||
| Langues parlées | English, French | ||||||||
| Séjours de recherche en | Belgium, France, Luxembourg, Switzerland | ||||||||
Current positions
- Since August 1, 2002: Professor of Physiology at the University of Luxembourg
- January 2012 - January 2017: Vice-President, University of Luxembourg
- Since 2016: member of the Management committee of the Luxembourg University Foundation
- Since January 2017: Special Advisor to the President, Tech Transfer & Fundraising.
Short bio
My research interests have been bronchial hyperreactivity delineation until the late 80s as a PhD student and endothelin receptor antagonist development in a US pharmaceutical research centre for cardiovascular and pulmonary targets until 1992.
As a group leader in the Centre de Recherche Public-Santé (Luxembourg), I then developed a research team to elucidate the control of superoxide anion secretion by calcium ion fluxes in human immune cells. Most developments implicated fluorescence measurement of biological and biochemical processes in live cellsin vitro, with a profound insight in the discovery of calcium-controlled transductional events leading to superoxide anions secretion. A complementary research activity linked to the investigation of oxidative stress consequences within the vascular wall was carried out.
Simultaneously, I taught physiology and pharmacology at the Centre Universitaire de Luxembourg (now University of Luxembourg) and at the University of Louvain (medical and pharmacy school) in Belgium.
After joining the University of Luxembourg late 2002, fluorescence-based studies became fully functional in autumn 2004. Aside, an interest was developed for the consequences of spaceflight on animal and human immunological system.
Since 2006, I have occupied various positions at the management of the University, being initially special advisor to the President for research management, then Director of Administration; after having managed Academic Affairs as Vice-president for nearly 5 years, I am in charge of Technology Transfer and Fundraising for the University, as Special Advisor to the President.
> Check my peer-reviewed publications.
Last updated on: mercredi 12 juillet 2017
Degrees
- Qualification "Fonctions de Professeur des Universités", section n°65: cell biology and section n°66: physiology, by the "Conseil National des Universités" (Journal Officiel de la République Française, n°147 du 267 juin 2001, page 10184), 2002
- Habilitation à diriger des recherches, University of Nancy I, 1994
- PhD in pharmacology, University of Strasbourg I, France,Paracrine regulation of bronchial smooth muscle tone (summa cum laude), 1986-1988
- Master in Business Administration (DESS-CAAE), Institut d'Administration des Entreprises, Université de Nancy II, 1997
Research Interests
- Inflammation, oxidative stress and calcium fluxes
- Oxidative stress and matrix metalloproteinases
- Development of applications of biophysical techniques to study physiological processes in live
- Cells or tissues, drug development application
- Pharmacology and pharmaco-chemistry of anti-inflammatory drugs
Supervision of 10 PhDs at European level
Membership in Scientific Societies
- American Physiological Society
- British Pharmacological Society
- French society of Pharmacology
Linkedin: linkedin.com/in/erictschirhart
Last updated on: 12 juil 2017
Member of Boards
- Former Member of the Board of the Centre de Recherche Public Gabriel Lippmann
- Member of the Board of Axoglia Therapeutics (representing the University and the Société Nationale de Crédit et d’Investissement)
- Member of the Management committee of the Luxembourg University Foundation
Evaluation Activities
- 2010: member of the International Evaluation Committee of the University of Rennes 1
- Since 2007, responsible and general coordinator for the evaluation process of the University of Luxembourg
- Recurrent reviewer for scientific journals (selection):
- Fund. Clin. Pharmacol.
- Eur. J. Pharmacol.
- Current Med. Chem.
- J. Med. Chem.
- Biochimica et Biophysica Acta
- Cell Calcium
- Thrombosis Research
- Bioorganic and Medicinal Chemistry
- Annals of Nutrition
- J. Pharmacol. Exp. Ther.
- Diabetologia
- External expert for research agencies (selection):
- INSERM (F)
- Agence Nationale de la Recherche (F)
- External expert for foreign universities
- Reviewer for research grants at University of Lille and INSERM
Last updated on: 12 juil 2017
Here is a selection of links to publications about my activities as Vice-President and as Special Advisor to the President, at the University of Luxembourg released in domestic and international media
2016 |
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| Date |
Title |
Media |
| 25.05.2016 |
Radio 100,7 |
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| 11.05.2016 |
Paperjam |
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| 25.04.2016 |
Paperjam |
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| 20.04.2016 |
Juste Avant de Zapper, 20 avril 2016 - L'université du Luxembourg a la cote (video) |
Mirabelle TV |
| 12.04.2016 |
Numen Europe et Labgroup accompagnent l’Université du Luxembourg dans sa transformation digitale |
Merkur |
| 11.04.2016 |
chronicle.lu |
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| 16.03.2016 |
L'essentiel |
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| 25.02.2016 |
Paperjam |
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2015 |
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| Date |
Title |
Media |
| 03.11.2015 |
Ideas from Europe: Oswald Schröder est le candidat pour le Luxembourg |
Paperjam |
| 28.10.2015 |
les frontaliers |
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| 04.10.2015 |
Le Quotidien |
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| 02.10.2015 |
Paperjam |
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| 29.09.2015 |
Radio 100,7 |
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| 24.09.2015 |
Paperjam |
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| 21.09.2015 |
Paperjam |
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| 16.09.2015 |
Michel Wurth : « Arcelor Mittal avait une responsabilité historique à Belval » |
Le Quotidien |
| 08.09.2015 |
Belval – Design, le nouveau restaurant universitaire ouvre ses portes |
Le Quotidien |
| 08.09.2015 |
Le Quotidien |
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| 03.07.2015 |
Paperjam |
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| 19.06.2015 |
Promotion du réseau -actions positives- par Lydia Mutsch lors des Greater Region Business Days |
gouvernement.lu |
| 16.05.2015 |
L’Université du Luxembourg dématérialise ses dossiers d’inscription |
Solutions numériques |
| 30.03.2015 |
Luxemburger Wort |
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| 23.03.2015 |
L'essentiel |
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| 30.01.2015 |
L'essentiel |
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| 21.01.2015 |
Au Luxembourg, un doctorat financé à 100% par les industriels |
letudiant.fr |
| 15.01.2015 |
L'essentiel |
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2014 |
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| Date |
Title |
Media |
| 20.12.2014 |
Inauguration des premières résidences universitaires à Belval |
Luxemburger Wort |
| 19.12.2014 |
Luxemburger Wort |
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| 11.09.2016 |
5vier.de |
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| 10.09.2014 |
Luxemburger Wort |
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| 15.04.2014 |
Peoplesphere.lu |
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| 04.04.2014 |
Paperjam |
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| 14.03.2014 |
Paperjam |
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| 10.03.2014 |
SIC Europa |
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| 21.02.2014 |
Enseignement universitaire ouvert : Révolution ou poudre aux yeux ? |
woxx |
| 29.01.2014 |
Aufgestockt: Neue Studiengänge für Ingenieure sollen mehr Studenten anlocken |
Journal.lu |
2013 |
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| Date |
Title |
Media |
| 12.09.2013 |
Paperjam |
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| 17.06.2013 |
Numen Europe dématérialise plus de 6.500 dossiers étudiants de l’Université du Luxembourg |
Paperjam |
| 18.06.2013 |
L’Université du Luxembourg dématérialise plus de 6500 dossiers étudiants |
ITnation.lu |
| 06-07.2013 |
soluxions Business Technologies |
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| 22.05.2013 |
A l'uni.lu, le luxembourgeois n'est pas utilisé pour les cours |
Luxemburger Wort |
2012 |
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| Date |
Title |
Media |
| 05.10.2012 |
Les étudiants attendent toujours une reconnaissance officielle : Jeunes travailleurs intellectuels |
Luxemburger Wort |
Last updated on: 12 juil 2017
2018
Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9.; ; ; ; ; ; ;
in Frontiers in immunology (2018), 9
2015
Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting; ; ; ; ;
in Journal of Immunology Research (2015), 2015
2014
An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2014), 97
2013
New Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling; ;
in Antioxidants & Redox Signaling (2013), 18(6), 661-676
The recruitment of p47 and Rac2G12V at the phagosome is transient and phosphatidylserine dependent.; ; ; ; ; ; ; ; ;
in Biology of the Cell (2013)
Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis; ; ; ; ; ; ;
in FASEB Journal (2013), 27(1), 333-341
2012
Role of the Neutrophil NADPH Oxidase and S100A8/A9 in the Pathophysiology of Chronic Inflammation; ;
in Khatami, Mahin (Ed.) Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases (2012)
Stress response and humoral immune system alterations related to chronic hypergravity in mice; ; ; ; ; ; ;
in Psychoneuroendocrinology (2012), 37(1), 137-147
2011
Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9; ; ; ;
in Journal of Leukocyte Biology (2011), 89(4), 587-596
An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity; ; ; ;
in Journal of Immunology (2011), 186(4), 2182-2191
2010
New biological investigations on 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate as anti-angiogenic agent; ; ; ; ; ; ; ; ; ;
in Drug Development Research (2010), 71
iPLA 2 , a novel determinant in Ca2+ - and phosphorylation-dependent S100A8/A9 regulated NOX2 activity; ; ; ; ;
in Biochimica et Biophysica Acta-Molecular Cell Research (2010), 1803(7), 840-847
2009
Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl; ; ; ;
in FASEB Journal (2009), 23(5), 1607-1615
STIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells; ; ;
in Biochemical Pharmacology (2009), 78(5), 504-513
OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca 2+ entry; ;
in Journal of Leukocyte Biology (2009), 85(4), 638-647
Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit?; ; ; ; ; ;
in Journal of Leukocyte Biology (2009), 86(5), 1027-1038
Les peptides opioïdes et autres médiateurs de la nociceptionin Landry, Yves; Gies, Jean-Pierre (Eds.) Pharmacologie. Des cibles vers l’indication thérapeutique (2009)
2008
Cell passaging rapidly affects expression, secretion and activity of MMP9 as well as mobility of HL60 leukemia cells; ; ; ;
in Journal of Cell and Animal Biology (2008), 2(9), 160-165
Regulation of superoxide production in neutrophils: role of calcium influx;
in Journal of Leukocyte Biology (2008), 84(5), 1223-1237
Ca2+-dependent regulation of NOX2 activity via MRP proteins in HL-60 granulocytes; ; ; ; ;
in Calcium Binding Proteins (2008), 3(1), 25-30
2006
Modulation by cADPr of Ca2+ mobilization and oxidative response in dimethylsulfoxide- or retinoic acid-differentiated HL-60 cells; ; ;
in Biochimica et Biophysica Acta (2006), 1763(1), 129-36
Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway; ; ; ;
in British Journal of Pharmacology (2006), 148(4), 544-52
2005
Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium; ;
in Cell Calcium (2005), 37(6), 531-40
The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Immunotoxicology (2005), 2(2), 61-83
Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells; ; ; ;
in Fundamental and Clinical Pharmacology (2005), 19(6), 661-7
2001
Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro; ;
in Biochimica et Biophysica Acta (2001), 1538(2-3), 252-9
Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle; ; ; ;
in Biochemical Pharmacology (2001), 61(9), 1169-75
Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle; ; ; ; ;
in Biochemical Pharmacology (2001), 61(4), 485-91
Rac-1-mediated O2- secretion requires Ca2+ influx in neutrophil-like HL-60 cells; ; ;
in Cell Calcium (2001), 29(6), 409-15
Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not nitric oxide;
in Inflammation Research (2001), 50(7), 357-61
2000
Pertussis toxin-sensitive G(i)-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery; ; ; ; ;
in British Journal of Pharmacology (2000), 131(7), 1337-44
1999
Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells; ;
in European Journal of Pharmacology (1999), 361(2-3), 293-8
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors; ; ; ; ; ; ; ;
in Biochimica et Biophysica Acta (1999), 1440(2-3), 266-74
Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium; ;
in Cell Calcium (1999), 25(5), 381-9
Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion;
in Thérapie (1999), 54(1), 103-9
1997
Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production; ; ; ;
in Journal of Immunological Methods (1997), 205(1), 1-9
1996
Endothelin-1 does not modulate O2.release and [Ca(2+)]i variations in resting or differentiated HL-60 cells; ;
in Fundamental and Clinical Pharmacology (1996), 10(1), 28-32
1995
A double-labelling fluorescent assay for concomitant measurements of [Ca2+]i and O2. production in human macrophages; ; ; ;
in Biochimica et Biophysica Acta (1995), 1244(1), 79-84
1993
An epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea; ; ; ;
in Pulmonary Pharmacology (1993), 6(1), 69-76
Epithelial factors: modulation of the airway smooth muscle tone;
in Fundamental and Clinical Pharmacology (1993), 7(6), 261-73
1992
Epithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis; ;
in Immunopharmacology (1992), 22(2), 115-25
1991
Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models; ;
in Agents and Actions. Supplements (1991), 31
Endothelins: functional and autoradiographic studies in guinea pig trachea; ; ; ;
in Journal of Pharmacology and Experimental Therapeutics (1991), 258(1), 381-7
Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21); ;
in Agents and Actions. Supplements (1991), 31
1990
Evidence for the involvement of calcitonin gene-related peptide in the epithelium-dependent contraction of guinea-pig trachea in response to capsaicin; ; ;
in Naunyn-Schmiedeberg's Archives of Pharmacology (1990), 342(2), 177-81
1989
Nedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea-pig trachea; ;
in International Archives of Allergy and Applied Immunology (1989), 88(4), 439-46
Activation of rat peritoneal mast cells by substance P and mastoparan; ; ; ; ;
in Journal of Pharmacology and Experimental Therapeutics (1989), 250(1), 329-35
Contractile activity of the N-acylated C-terminal part of substance P7-11 in guinea pig trachea. Effect of epithelium removal; ; ; ; ; ;
in Naunyn-Schmiedeberg's Archives of Pharmacology (1989), 340(1), 107-10
1987
Arachidonic acid metabolites and airway epithelium-dependent relaxant factor; ; ;
in Journal of Pharmacology and Experimental Therapeutics (1987), 243(1), 310-6
Airway epithelium releases a relaxant factor: demonstration with substance P;
in European Journal of Pharmacology (1987), 132(1), 103-4
