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Dr. Claude Haan
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| Faculté ou Centre | Faculté des Sciences, des Technologies et de Médecine | ||||
| Department | Département Sciences de la vie et médecine | ||||
| Adresse postale |
Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Bureau sur le campus | BioTech II, 4.25 | ||||
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| Téléphone | (+352) 46 66 44 6438 | ||||
2020
Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types; ; ; ; ; ; ; ; ;
in Journal of Molecular Biology (2020)
2019
Many ways to resistance: How melanoma cells evade targeted therapies; ; ; ;
in Biochimica et Biophysica Acta - Reviews on Cancer (2019), 1871(2), 313-322
Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells; ; ; ; ; ; ; ;
in Journal of Experimental and Clinical Cancer Research (2019), 38(1),
Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3; ; ; ; ; ; ;
in Molecular Therapy: Nucleic Acids (2019), 16
2018
A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Cancer (2018), (17:145),
The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2018), 104
2017
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells; ; ; ; ; ; ; ; ; ;
in Cellular Signalling (2017), 35
ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells; ; ; ;
in Molecular Cancer (2017), 8(june),
Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines; ; ; ; ; ; ; ; ; ; ;
in BBA Molecular Cell Research (2017)
2016
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.; ; ; ; ; ; ;
in Cancer and Metabolism (2016), 4
2015
The oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.; ; ; ; ; ; ; ; ; ; ;
in JAK-STAT (2015), 4(1), 1062596
ID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases; ; ; ; ; ; ; ; ;
in Cytokine (2015), 76(1), 99-
2013
JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms; ;
in JAK-STAT (2013), 2(3), 25025
Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F; ; ; ; ; ; ; ;
in Journal of Cellular and Molecular Medicine (2013), 17(2), 265-276
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.;
in Methods in Molecular Biology (2013), 967
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.;
in Methods in Molecular Biology (2013), 967
JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.; ; ; ; ; ; ; ;
in JAK-STAT (2013), 2(3), 24574
2012
Regulation of JAKs: Insights gleaned from the functional protein domains; ; ; ;
in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)
2011
Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors; ; ; ; ; ; ;
in Chemistry and Biology (2011), 18(3), 314-323
2010
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.; ;
in Journal of Cellular and Molecular Medicine (2010), 14(3), 504-27
Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells; ;
in Biochemical Pharmacology (2010), 80(12), 2066-2073
2009
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.; ; ; ; ; ; ; ; ;
in Hepatology (2009), 50(2), 585-91
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses; ; ; ; ; ; ; ;
in Journal of Immunology (2009), 182(5), 2969-2977
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.; ; ; ; ; ;
in Oncogene (2009), 28(34), 3069-80
Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression; ; ; ;
in Journal of Immunology (2009), 181(10), 7341-7349
Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling; ; ; ; ; ; ; ;
in Hepatology (2009), 2009(3),
2008
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation; ; ; ; ; ; ;
in Journal of Immunology (2008), 180(2), 998-1007
2007
A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background;
in Journal of Immunological Methods (2007), 318(1-2), 11-9
Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells; ; ; ; ; ; ;
in PLoS ONE (2007), 2(12), 1300
2006
Jaks and cytokine receptors - an intimate relationship; ; ;
in Biochemical Pharmacology (2006), 72(11), 1538-46
2005
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation; ; ; ;
in Cellular Signalling (2005), 17(12), 1542-50
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2005), 280(27), 25760-8
2004
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(34), 35486-93
2003
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis; ; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(40), 39205-13
2002
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 277(13), 11297-305
2001
Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation; ;
in Biochemical Journal (2001), 361(Pt 1), 105-11
A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction; ; ;
in Biochemical Journal (2001), 349(Pt 1), 261-6
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction; ; ; ; ; ; ;
in Journal of Biological Chemistry (2001), 276(40), 37451-8
2000
Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor; ; ; ; ; ;
in European Cytokine Network (2000), 11(3), 491-2
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130; ; ; ; ; ;
in Journal of Immunology (2000), 163(12), 6651-8
Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis; ; ; ; ; ;
in FEBS Letters (2000), 470(1), 15-9
