Aurélien Ginolhac

A Ginolhac

Research scientist

Faculté ou Centre Faculté des Sciences, des Technologies et de Médecine
Department Département Sciences de la vie et médecine
Adresse postale Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Bureau sur le campus BioTech II Ketterthill, 4.03
E-mail
Téléphone (+352) 46 66 44 6560

Responsible of the Bioinformatic Core position at the Life Sciences Research Unit

Last updated on: lundi 30 septembre 2019

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2022

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See detailFocal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma
Del Mistro, Greta; Riemann, Shamala; Schindler, Sebastian; Beissert, Stefan; Kontermann, Roland E; Ginolhac, Aurélien; Halder, Rashi; Presta, Luana; Sinkkonen, Lasse; Sauter, Thomas; Kulms, Dagmar

in Cell Death and Disease (2022)

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2021

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See detailNF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells
Grandbarbe, Luc; Michelucci, Alessandro; Heuschling, Paul; Pavlou, Maria Angeliki; Ginolhac, Aurélien

in Cells (2021)

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2020

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See detailSystematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types
Kirchmeyer, Mélanie; Servais, Florence; Ginolhac, Aurélien; Nazarov, Petr V.; Margue, Christiane; Philippidou, Demetra; Nicot, Nathalie; Behrmann, Iris; Haan, Claude; Kreis, Stephanie

in Journal of Molecular Biology (2020)

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See detailReduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice
Klaus, Christine; Hansen, Jan N.; Ginolhac, Aurélien; Gérard, Deborah; Gnanapragassam, Vinayaga S.; Horstkorte, Rüdiger; Rossdam, Charlotte; Buettner, Falk F. R.; Sauter, Thomas; Sinkkonen, Lasse; Neumann, Harald; Linnartz-Gerlach, Bettina

in Neurobiology of Aging (2020)

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See detailPhagocytosis‐related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides
Shahraz, Anahita; Wißfeld, Jannis; Ginolhac, Aurélien; Matthews, Mona; Sinkkonen, Lasse; Neumann, Harald

in Glia (2020)

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See detailUnderstanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression
Ternes, Dominik; Karta, Jessica; Tsenkova, Mina; Koncina, Eric; Schmitz, Martine; Grandmougin, Léa; Ginolhac, Aurélien; Gaigneaux, Anthoula; Ramiro Garcia, Javier; Wilmes, Paul; Haan, Serge; Letellier, Elisabeth

Poster (2020, February 22)

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2019

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See detailIdentification of genes under dynamic post-transcriptional regulation from time-series epigenomic data
Becker, Julia Christina; Gerard, Déborah; Ginolhac, Aurélien; Sauter, Thomas; Sinkkonen, Lasse

in Epigenomics (2019)

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See detailEarly Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny.
Cappellini, Enrico; Welker, Frido; Pandolfi, Luca; Ramos-Madrigal, Jazmin; Samodova, Diana; Ruther, Patrick L.; Fotakis, Anna K.; Lyon, David; Moreno-Mayar, J. Victor; Bukhsianidze, Maia; Rakownikow Jersie-Christensen, Rosa; Mackie, Meaghan; Ginolhac, Aurélien; Ferring, Reid; Tappen, Martha; Palkopoulou, Eleftheria; Dickinson, Marc R.; Stafford, Thomas W. Jr; Chan, Yvonne L.; Gotherstrom, Anders; Nathan, Senthilvel K. S. S.; Heintzman, Peter D.; Kapp, Joshua D.; Kirillova, Irina; Moodley, Yoshan; Agusti, Jordi; Kahlke, Ralf-Dietrich; Kiladze, Gocha; Martinez-Navarro, Bienvenido; Liu, Shanlin; Sandoval Velasco, Marcela; Sinding, Mikkel-Holger S.; Kelstrup, Christian D.; Allentoft, Morten E.; Orlando, Ludovic; Penkman, Kirsty; Shapiro, Beth; Rook, Lorenzo; Dalen, Love; Gilbert, M. Thomas P.; Olsen, Jesper V.; Lordkipanidze, David; Willerslev, Eske

in Nature (2019)

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2018

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See detailTemporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency
Gerard, Déborah; Schmidt, Florian; Ginolhac, Aurélien; Schmitz, Martine; Halder, Rashi; Ebert, Peter; Schulz, Marcel; Sauter, Thomas; Sinkkonen, Lasse

in Nucleic Acids Research (2018)

See detailUL HPC Tutorial: Statistical Computing with R
Ginolhac, Aurélien; Emeras, Joseph; Varrette, Sébastien; Plugaru, Valentin; Diehl, Sarah; Parisot, Clément; Cartiaux, Hyacinthe; Bouvry, Pascal

Presentation (2018, June)

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See detailCytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Kirchmeyer, Melanie; Servais, Florence; Hamdorf, Matthias; Nazarov, Petr V.; Ginolhac, Aurélien; Halder, Rashi; Vallar, Laurent; Glanemann, Matthias; Rubie, Claudia; Lammert, Frank; Kreis, Stephanie; Behrmann, Iris

in Journal of leukocyte biology (2018)

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See detailTREM2 triggers microglial density and age‐related neuronal loss
Linnartz-Gerlach, Bettina; Bodea, Liviu-Gabriel; Klaus, Christine; Ginolhac, Aurélien; Halder, Rashi; Sinkkonen, Lasse; Walter, Jochen; Colonna, Marco; Neumann, Harald

in Glia (2018)

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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See detailThe microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis.
Ullmann, Pit; Rodriguez, Fabien; Schmitz, Martine; Meurer, Steffen K.; Qureshi-Baig, Komal; Felten, Paul; Ginolhac, Aurélien; Antunes, Laurent; Frasquilho, Sonia; Zugel, Nikolaus; Weiskirchen, Ralf; Haan, Serge; Letellier, Elisabeth

in Cancer research (2018)

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2017

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See detailLoss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence
Letellier, Elisabeth; Schmitz, Martine; Ginolhac, Aurélien; Rodriguez, Fabien; Ullmann, Pit; Qureshi-Baig, Komal; Frasquilho, Sonia; Antunes, Laurent; Haan, Serge

in British Journal of Cancer (2017), 117(11), 1689-1701

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See detailCrosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
Rolvering, Catherine; Zimmer, Andreas; Kozar, Ines; Hermanns; Letellier, Elisabeth; Vallar, Laurent; Nazarov, Petr; Nicot, Nathalie; Ginolhac, Aurélien; Haan, Serge; Behrmann, Iris; Haan, Claude

in BBA Molecular Cell Research (2017)

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2016

See detail“Melanomics”: analysis and integration of whole genomes, transcriptomes and miRNomes of primary melanoma patients
Reinsbach, Susanne; Wienecke, Anke; Ginolhac, Aurélien; Vallar, Laurent; Krishna; Krishna, Abhimanyu; Nazarov, Petr; May, Patrick; Kreis, Stephanie

in European Journal of Cancer (2016), 61(Suppl.1), 32

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See detailHypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production
Ullmann, Pit; qureshi-baig, komal; Rodriguez, Fabien; Ginolhac, Aurélien; nonnenmacher, yannic; Ternes, Dominik; Weiler, Jil; Gaebler, Karoline; bahlawane, Christelle; hiller, karsten; Haan, Serge; Letellier, Elisabeth

in Oncotarget (2016), 7(40), 97-114

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2015

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See detailEvolutionary Genomics and Conservation of the Endangered Przewalski's Horse.
Der Sarkissian, Clio; Ermini, Luca; Schubert, Mikkel; Yang, Melinda A.; Librado, Pablo; Fumagalli, Matteo; Jonsson, Hakon; Bar-Gal, Gila Kahila; Albrechtsen, Anders; Vieira, Filipe G.; Petersen, Bent; Ginolhac, Aurélien; Seguin-Orlando, Andaine; Magnussen, Kim; Fages, Antoine; Gamba, Cristina; Lorente-Galdos, Belen; Polani, Sagi; Steiner, Cynthia; Neuditschko, Markus; Jagannathan, Vidhya; Feh, Claudia; Greenblatt, Charles L.; Ludwig, Arne; Abramson, Natalia I.; Zimmermann, Waltraut; Schafberg, Renate; Tikhonov, Alexei; Sicheritz-Ponten, Thomas; Willerslev, Eske; Marques-Bonet, Tomas; Ryder, Oliver A.; McCue, Molly; Rieder, Stefan; Leeb, Tosso; Slatkin, Montgomery; Orlando, Ludovic

in Current Biology (2015), 25(19), 2577-83

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See detailRole of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells
Dorosz, Susann Antonia; Ginolhac, Aurélien; Kähne, Thilo; Naumann, Michael; Sauter, Thomas; Salsmann, Alexandre; Bueb, Jean-Luc

in Mediators of Inflammation (2015), 2015

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2014

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See detailSpeciation with gene flow in equids despite extensive chromosomal plasticity.
Jonsson, Hakon; Schubert, Mikkel; Seguin-Orlando, Andaine; Ginolhac, Aurélien; Petersen, Lillian; Fumagalli, Matteo; Albrechtsen, Anders; Petersen, Bent; Korneliussen, Thorfinn S.; Vilstrup, Julia T.; Lear, Teri; Myka, Jennifer Leigh; Lundquist, Judith; Miller, Donald C.; Alfarhan, Ahmed H.; Alquraishi, Saleh A.; Al-Rasheid, Khaled A. S.; Stagegaard, Julia; Strauss, Gunter; Bertelsen, Mads Frost; Sicheritz-Ponten, Thomas; Antczak, Douglas F.; Bailey, Ernest; Nielsen, Rasmus; Willerslev, Eske; Orlando, Ludovic

in Proceedings of the National Academy of Sciences of the United States of America (2014), 111(52), 18655-60

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See detailCharacterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX.
Schubert, Mikkel; Ermini, Luca; Der Sarkissian, Clio; Jonsson, Hakon; Ginolhac, Aurélien; Schaefer, Robert; Martin, Michael D.; Fernandez, Ruth; Kircher, Martin; McCue, Molly; Willerslev, Eske; Orlando, Ludovic

in Nature protocols (2014), 9(5), 1056-82

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See detailPrehistoric genomes reveal the genetic foundation and cost of horse domestication.
Schubert, Mikkel; Jonsson, Hakon; Chang, Dan; Der Sarkissian, Clio; Ermini, Luca; Ginolhac, Aurélien; Albrechtsen, Anders; Dupanloup, Isabelle; Foucal, Adrien; Petersen, Bent; Fumagalli, Matteo; Raghavan, Maanasa; Seguin-Orlando, Andaine; Korneliussen, Thorfinn S.; Velazquez, Amhed M. V.; Stenderup, Jesper; Hoover, Cindi A.; Rubin, Carl-Johan; Alfarhan, Ahmed H.; Alquraishi, Saleh A.; Al-Rasheid, Khaled A. S.; MacHugh, David E.; Kalbfleisch, Ted; MacLeod, James N.; Rubin, Edward M.; Sicheritz-Ponten, Thomas; Andersson, Leif; Hofreiter, Michael; Marques-Bonet, Tomas; Gilbert, M. Thomas P.; Nielsen, Rasmus; Excoffier, Laurent; Willerslev, Eske; Shapiro, Beth; Orlando, Ludovic

in Proceedings of the National Academy of Sciences of the United States of America (2014), 111(52), 5661-9

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2013

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See detailmapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters.
Jonsson, Hakon; Ginolhac, Aurélien; Schubert, Mikkel; Johnson, Philip L. F.; Orlando, Ludovic

in Bioinformatics (2013), 29(13), 1682-4

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See detailRecalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse.
Orlando, Ludovic; Ginolhac, Aurélien; Zhang, Guojie; Froese, Duane; Albrechtsen, Anders; Stiller, Mathias; Schubert, Mikkel; Cappellini, Enrico; Petersen, Bent; Moltke, Ida; Johnson, Philip L. F.; Fumagalli, Matteo; Vilstrup, Julia T.; Raghavan, Maanasa; Korneliussen, Thorfinn; Malaspinas, Anna-Sapfo; Vogt, Josef; Szklarczyk, Damian; Kelstrup, Christian D.; Vinther, Jakob; Dolocan, Andrei; Stenderup, Jesper; Velazquez, Amhed M. V.; Cahill, James; Rasmussen, Morten; Wang, Xiaoli; Min, Jiumeng; Zazula, Grant D.; Seguin-Orlando, Andaine; Mortensen, Cecilie; Magnussen, Kim; Thompson, John F.; Weinstock, Jacobo; Gregersen, Kristian; Roed, Knut H.; Eisenmann, Vera; Rubin, Carl J.; Miller, Donald C.; Antczak, Douglas F.; Bertelsen, Mads F.; Brunak, Soren; Al-Rasheid, Khaled A. S.; Ryder, Oliver; Andersson, Leif; Mundy, John; Krogh, Anders; Gilbert, M. Thomas P.; Kjaer, Kurt; Sicheritz-Ponten, Thomas; Jensen, Lars Juhl; Olsen, Jesper V.; Hofreiter, Michael; Nielsen, Rasmus; Shapiro, Beth; Wang, Jun; Willerslev, Eske

in Nature (2013), 499(7456), 74-8

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See detailMitochondrial phylogenomics of modern and ancient equids.
Vilstrup, Julia T.; Seguin-Orlando, Andaine; Stiller, Mathias; Ginolhac, Aurélien; Raghavan, Maanasa; Nielsen, Sandra C. A.; Weinstock, Jacobo; Froese, Duane; Vasiliev, Sergei K.; Ovodov, Nikolai D.; Clary, Joel; Helgen, Kristofer M.; Fleischer, Robert C.; Cooper, Alan; Shapiro, Beth; Orlando, Ludovic

in PloS one (2013), 8(2), 55950

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2012

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See detailProteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins.
Cappellini, Enrico; Jensen, Lars J.; Szklarczyk, Damian; Ginolhac, Aurélien; da Fonseca, Rute A. R.; Stafford, Thomas W.; Holen, Steven R.; Collins, Matthew J.; Orlando, Ludovic; Willerslev, Eske; Gilbert, M. Thomas P.; Olsen, Jesper V.

in Journal of proteome research (2012), 11(2), 917-26

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See detailImproving the performance of true single molecule sequencing for ancient DNA.
Ginolhac, Aurélien; Vilstrup, Julia; Stenderup, Jesper; Rasmussen, Morten; Stiller, Mathias; Shapiro, Beth; Zazula, Grant; Froese, Duane; Steinmann, Kathleen E.; Thompson, John F.; Al-Rasheid, Khaled A. S.; Gilbert, Thomas M. P.; Willerslev, Eske; Orlando, Ludovic

in BMC genomics (2012), 13

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See detailImproving ancient DNA read mapping against modern reference genomes.
Schubert, Mikkel; Ginolhac, Aurélien; Lindgreen, Stinus; Thompson, John F.; Al-Rasheid, Khaled A. S.; Willerslev, Eske; Krogh, Anders; Orlando, Ludovic

in BMC genomics (2012), 13

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2011

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See detailmapDamage: testing for damage patterns in ancient DNA sequences.
Ginolhac, Aurélien; Rasmussen, Morten; Gilbert, M. Thomas P.; Willerslev, Eske; Orlando, Ludovic

in Bioinformatics (2011), 27(15), 2153-5

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See detailTrue single-molecule DNA sequencing of a pleistocene horse bone.
Orlando, Ludovic; Ginolhac, Aurélien; Raghavan, Maanasa; Vilstrup, Julia; Rasmussen, Morten; Magnussen, Kim; Steinmann, Kathleen E.; Kapranov, Philipp; Thompson, John F.; Zazula, Grant; Froese, Duane; Moltke, Ida; Shapiro, Beth; Hofreiter, Michael; Al-Rasheid, Khaled A. S.; Gilbert, M. Thomas P.; Willerslev, Eske

in Genome research (2011), 21(10), 1705-19

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