Dr. Christiane Wurth-Margue

Christiane Wurth-Margue

Research scientist

Faculté ou Centre Faculté des Sciences, de la Technologie et de la Communication
Unité de recherche RU Life Sciences
Adresse postale Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Bureau sur le campus BioTech II, 4.25
Téléphone (+352) 46 66 44 6433

Academic degrees:

PhD in Biochemistry
Swiss Federal Institute of Technology Zurich (ETHZ) (2000)
MSc in Biology
Swiss Federal Institute of Technology Zurich (ETHZ) (1996)

Current research projects/interests:

  1. Regulation of microRNA expression by transcription factors: relevance for cancer development (melanoma). Investigation and description of a complete regulatory line of events starting with cytokine stimulations of different cancer cells → STAT induction → identification of STAT-regulated miRNAs → identification and analysis of miRNA target genes → functional role of target genes in cancer.
  2. Identification and investigation of miRNAs as potential biomarkers for cancer (melanoma) development and progression.
  3. Jak/STAT signaling in melanoma cells.


Last updated on: vendredi 16 février 2018

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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See detailImpact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells
Kreis, Stephanie; Kozar, Ines; Cesi, Giulia; Margue, Christiane; Philippidou, Demetra

in Biochimica et Biophysica Acta (2017)

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See detailThe TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner
Kreis, Stephanie; Margue, Christiane; Heulot, M; Chevalier, N; Puyal, J; Kulms, D; Michel, S; Barras, D; Nahimana, A; Widmann, C

in Oncotarget (2016)

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See detailCirculating microRNAs as candidate biomarkers for the surveillance of melanoma patients
Behrmann, Iris; Margue, Christiane; Kreis, Stephanie

in EBioMedicine (2015)

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See detailComparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?
Margue, Christiane; Reinsbach, Susanne; Philippidou, Demetra; Beaume, Nicolas; Walters, Casandra; Schneider, Jochen; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Oncotarget (2015), 6(14), 12110-27

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See detailNew Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion
Margue, Christiane; Philippidou, Demetra; Reinsbach, Susanne; Schmitt, Martina; Behrmann, Iris; Kreis, Stephanie

in PLoS ONE (2013)

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See detailMiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties
Schmitt, Martina; Margue, Christiane; Behrmann, Iris; Kreis, Stephanie

in Current Molecular Medicine (2012), 13(4), 572-585

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See detailInterferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells
Schmitt, Martina; Philippidou, Demetra; Reinsbach, Susanne; Margue, Christiane; Wienecke-Baldacchino, Anke; Nashan, D. C; Behrmann, Iris; Kreis, Stephanie

in Cell Communication and Signaling (2012), 10

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See detailIL-24: Physiological and supraphysiological effects on normal and malignant cells
Margue, Christiane; Kreis, Stephanie

in Current Medicinal Chemistry (2010), 17(29), 3318-3326

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See detailSignatures of MicroRNAs and selected MicroRNA target genes in human melanoma
Philippidou, Demetra; Schmitt, Martina; Moser, D. A; Margue, Christiane; Nazarov, P. V. B; Muller, A. B; Vallar, L. B; Nashan, D. C; Behrmann, Iris; Kreis, Stephanie

in Cancer Research (2010), 70(10), 4163-4173

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See detailDual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
Haan, Serge; Margue, Christiane; Engrand, A.; Rolvering, Catherine; Schmitz-Van de Leur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Immunology (2008), 180(2), 998-1007

See detailIL-24: a classic cytokine and/or a potential cure for cancer?
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Behrmann, Iris

in Journal of Cellular & Molecular Medicine (2008)

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See detailRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Rolvering, Catherine; Haan, Claude; Dumoutier, L.; Renauld, J. C.; Behrmann, Iris

in PLoS ONE (2007), 2(12), 1300

See detailComplete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.
Schmitz, Martine; Grignard, Gerard; Margue, Christiane; Dippel, Walter; Capesius, Catherine; Mossong, Joel; Nathan, Michel; Giacchi, Sandro; Scheiden, Rene; Kieffer, Nelly

in International Journal of Cancer = Journal International du Cancer (2007), 120(6), 1284-92

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See detailJaks and cytokine receptors - an intimate relationship
Haan, Claude; Kreis, Stephanie; Margue, Christiane; Behrmann, Iris

in Biochemical Pharmacology (2006), 72(11), 1538-46

See detailTransferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons"
Kreis, Stephanie; Cesi, Giulia; Walbrecq, Geoffroy; Margue, Christiane

in Cell Communication and Signaling (2006), 14(1), 13

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See detailIntegrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone.
Pecheur, Isabelle; Peyruchaud, Olivier; Serre, Claire-Marie; Guglielmi, Julien; Voland, Carole; Bourre, Francois; Margue, Christiane; Cohen-Solal, Martine; Buffet, Annie; Kieffer, Nelly; Clezardin, Philippe

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2002), 16(10), 1266-8

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See detailTranscriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR
Margue, Christiane; Bernasconi, Michele; Barr, Frederik; Schäfer, Beat

in Oncogene (2000), 19(25), 2921

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See detailQuantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs.
Filser, N.; Margue, Christiane; Richter, C.

in Biochemical and biophysical research communications (1997), 233(1), 102-7

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