Publications

2018

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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See detailThe microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis.
Ullmann, Pit; Rodriguez, Fabien; Schmitz, Martine; Meurer, Steffen K.; Qureshi-Baig, Komal; Felten, Paul; Ginolhac, Aurélien; Antunes, Laurent; Frasquilho, Sonia; Zugel, Nikolaus; Weiskirchen, Ralf; Haan, Serge; Letellier, Elisabeth

in Cancer research (2018)

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2017

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See detailInsights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.
Bahlawane, Christelle; Schmitz, Martine; Letellier, Elisabeth; Arumugam, Karthik; Nicot, Nathalie; Nazarov, Petr; Haan, Serge

in Cell Signal (2017)

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See detailLoss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence
Letellier, Elisabeth; Schmitz, Martine; Ginolhac, Aurélien; Rodriguez, Fabien; Ullmann, Pit; Qureshi-Baig, Komal; Frasquilho, Sonia; Antunes, Laurent; Haan, Serge

in British Journal of Cancer (2017), 117(11), 1689-1701

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See detailTumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
qureshi-baig, komal; Ullmann, Pit; Haan, Serge; Letellier, Elisabeth

in Molecular Cancer (2017)

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See detailCrosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
Rolvering, Catherine; Zimmer, Andreas; Kozar, Ines; Hermanns; Letellier, Elisabeth; Vallar, Laurent; Nazarov, Petr; Nicot, Nathalie; Ginolhac, Aurélien; Haan, Serge; Behrmann, Iris; Haan, Claude

in BBA Molecular Cell Research (2017)

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See detailFrom meta-genomics to causality: Understanding the role of colon cancer-associated bacteria in colorectal cancer
Ternes, Dominik; Wilmes, Paul; Letellier, Elisabeth; Haan, Serge

Poster (2017, February 05)

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2016

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See detailData on quantification of signaling pathways activated by KIT and PDGFRA mutants.
Bahlawane, Christelle; Schmitz, Martine; Letellier, Elisabeth; Arumugam, Karthik; Nicot, Nathalie; Nazarov, Petr; Haan, Serge

in Data in Brief (2016)

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See detailSOCS2: physiological and pathological functions.
Letellier, Elisabeth; Haan, Serge

in Frontiers in bioscience (Elite edition) (2016), 8

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See detailDissecting functions of the N-terminal domain and GAS-site recognition in STAT3
Martincuks, Antons; Fahrenkamp, Dirk; Haan, Serge; Herrmann, Andreas; Küster, Andrea; Müller-Newen, Gerhard

in Cellular Signalling (2016), 28(8), 810-25

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See detailWhat Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue.
Qureshi-Baig, Komal; Ullmann, Pit; Rodriguez, Fabien; frasquilho, sonia; nazarov, peter; Haan, Serge; Letellier, Elisabeth

in PLoS ONE (2016), 11

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See detailA Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST.
Trairatphisan, Panuwat; Wiesinger, Monique; Bahlawane, Christelle; Haan, Serge; Sauter, Thomas

in PloS one (2016), 11(5), 0156223

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See detailHypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production
Ullmann, Pit; qureshi-baig, komal; Rodriguez, Fabien; Ginolhac, Aurélien; nonnenmacher, yannic; Ternes, Dominik; Weiler, Jil; Gaebler, Karoline; bahlawane, Christelle; hiller, karsten; Haan, Serge; Letellier, Elisabeth

in Oncotarget (2016)

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2015

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See detailConstitutive activation of oncogenic PDGFRalpha-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRalpha signalling characteristics.
Bahlawane, Christelle; Eulenfeld, Rene; Wiesinger, Monique; Wang, Jiali; Muller, Arnaud; Girod, Andreas; Nazarov, Petr V.; Felsch, Kathrin; Vallar, Laurent; Sauter, Thomas; Satagopam, Venkata; Haan, Serge

in Cell Communication and Signaling (2015), 13

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See detailThe oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.
Haan, Serge; Bahlawane, Christelle; Wang, Jiali; Nazarov, Petr V.; Muller, Arnaud; Eulenfeld, Rene; Haan, Claude; Rolvering, Catherine; Vallar, Laurent; Satagopam, Venkata; Sauter, Thomas; Wiesinger, Monique

in JAK-STAT (2015), 4(1), 1062596

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2014

See detailKapitel 34: Mediatoren
Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)

See detailKapitel 35: Rezeptoren und ihre Signaltransduktion
Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)

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See detailIdentification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.
Letellier, Elisabeth; Schmitz, Martine; Baig, Komal; Beaume, Nicolas; Schwartz, C.; Frasquilho, S.; Antunes, L.; Marcon, N.; Nazarov, P. V.; Vallar, L.; Even, J.; Haan, Serge

in British journal of cancer (2014), 111(4), 726-35

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2013

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See detailJAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.
Wolf, Alexandra; Eulenfeld, Rene; Gäbler, Karoline; Rolvering, Catherine; Haan, Serge; Behrmann, Iris; Denecke, Bernd; Haan, Claude; Schaper, Fred

in JAK-STAT (2013), 2(3), 24574

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2012

See detailRegulation of JAKs: Insights gleaned from the functional protein domains
Haan, Claude; Ungureanu, Daniela; Pekkala, Tuija; Silvennoinen, Olli; Haan, Serge

in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)

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2010

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See detailPerspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan, Claude; Behrmann, Iris; Haan, Serge

in Journal of Cellular & Molecular Medicine (2010), 14(3), 504-27

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See detailInterleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses.
Schoenherr, Caroline; Weiskirchen, Ralf; Haan, Serge

in Cell Communication and Signaling (2010), 8

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2009

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See detailInterleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Bender, Herdis; Wiesinger, Monique; Nordhoff, Carolin; Schoenherr, Caroline; Haan, Claude; Ludwig, Stephan; Weiskirchen, Ralf; Kato, Nobuyuki; Heinrich, Peter C.; Haan, Serge

in Hepatology (Baltimore, Md.) (2009), 50(2), 585-91

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See detailAn unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
Haan, Claude; Kroy, Daniela C.; Wüller, Stefan; Sommer, Ulrike; Nöcker, Tanja; Rolvering, Catherine; Behrmann, Iris; Heinrich, Peter C.; Haan, Serge

in Journal of Immunology (2009), 182(5), 2969-2977

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See detailSOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Haan, Serge; Wuller, S.; Kaczor, Jakub; Rolvering, Catherine; Nocker, T.; Behrmann, Iris; Haan, Claude

in Oncogene (2009), 28(34), 3069-80

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See detailDevelopment of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).
Wiesinger, Monique; Haan, Serge; Wuller, Stefan; Kauffmann, Maria-Elisabeth; Recker, Tobias; Kuster, Andrea; Heinrich, Peter C.; Muller-Newen, Gerhard

in Chemistry & Biology (2009), 16(7), 783-94

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2008

See detailDual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
Haan, Serge; Margue, Christiane; Engrand, A.; Rolvering, Catherine; Schmitz-Van de Leur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Immunology (2008), 180(2), 998-1007

See detailCell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
Kreis, Stephanie; Munz, G. A.; Haan, Serge; Heinrich, P. C.; Behrmann, Iris

in Molecular Cancer Research (2008), 5(12), 1331-41

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2007

See detailKapitel 25: Kommunikation zwischen Zellen: Extrazelluläre Signalmoleküle, Rezeptoren und Signaltransduktion
Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Löffler, Georg; Müller-Newen, Gerhard; Schaper, Fred

in Löffler, Georg; Petrides, P. E.; Heinrich, Peter C. (Eds.) Biochemie und Pathobiochemie (2007)

See detailNucleocytoplasmic shuttling of persistently activated STAT3.
Herrmann, Andreas; Vogt, Michael; Monnigmann, Martin; Clahsen, Thomas; Sommer, Ulrike; Haan, Serge; Poli, Valeria; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of Cell Science (2007), 120(Pt 18), 3249-61

See detailSustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
Isomoto, Hajime; Mott, Justin L.; Kobayashi, Shogo; Werneburg, Nathan W.; Bronk, Steve F.; Haan, Serge; Gores, Gregory J.

in Gastroenterology (2007), 132(1), 384-96

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2006

See detailDeterminants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.
Lehmann, Ute; Sommer, Ulrike; Smyczek, Tanya; Hortner, Michael; Frisch, Wiltrud; Volkmer-Engert, Rudolf; Heinrich, Peter C.; Schaper, Fred; Haan, Serge

in Cellular Signalling (2006), 18(1), 40-9

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2005

See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge; Keller, J. F.; Behrmann, Iris; Heinrich, P. C.; Haan, Claude

in Cellular Signalling (2005), 17(12), 1542-50

See detailBow to your partner for signaling.
Hermanns, Heike M.; Muller-Newen, Gerhard; Heinrich, Peter C.; Haan, Serge

in Nature Structural & Molecular Biology (2005), 12(6), 476-8

See detailAre STATS arginine-methylated?
Komyod, W.; Bauer, U. M.; Heinrich, P. C.; Haan, Serge; Behrmann, Iris

in Journal of Biological Chemistry (2005), 280(23), 21700-5

See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge; Jörissen, A.; Hermanns, H. M.; Diefenbach, S.; Smyczek, T.; Schmitz-Vandeleur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Biological Chemistry (2005), 280(27), 25760-8

See detailMechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
Sommer, Ulrike; Schmid, Christine; Sobota, Radoslaw M.; Lehmann, Ute; Stevenson, Nigel J.; Johnston, James A.; Schaper, Fred; Heinrich, Peter C.; Haan, Serge

in Journal of Biological Chemistry (2005), 280(36), 31478-88

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2004

See detailJanus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase
Behrmann, Iris; Smyczek, Tanja; Heinrich, Peter C.; Schmitz-Van de Leur, Hildegard; Komyod, Waraporn; Giese, Bernd; Muller-Newen, Gerhard; Haan, Serge; Haan, Claude

in Journal of Biological Chemistry (2004), 279(34), 35486-93

See detailThe role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
Fischer, P.; Lehmann, U.; Sobota, R. M.; Schmitz, J.; Niemand, C.; Linnemann, S.; Haan, Serge; Behrmann, Iris; Yoshimura, A.; Johnston, J. A.; Müller-Newen, G.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2004), 378(Pt 2), 449-60

See detailSTAT3 is enriched in nuclear bodies.
Herrmann, Andreas; Sommer, Ulrike; Pranada, Albert L.; Giese, Bernd; Kuster, Andrea; Haan, Serge; Becker, Walter; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of Cell Science (2004), 117(Pt 2), 339-49

See detailThe chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression.
Stevenson, Nigel J.; Haan, Serge; McClurg, Angela E.; McGrattan, Michael J.; Armstrong, Marilyn A.; Heinrich, Peter C.; Johnston, James A.

in Journal of immunology (Baltimore, Md. : 1950) (2004), 173(5), 3243-9

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2003

See detailA fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.
Ancey, Cecile; Kuster, Andrea; Haan, Serge; Herrmann, Andreas; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of Biological Chemistry (2003), 278(19), 16968-72

See detailTyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
Haan, Serge; Ferguson, Paul; Sommer, Ulrike; Hiremath, Meena; McVicar, Daniel W.; Heinrich, Peter C.; Johnston, James A.; Cacalano, Nicholas A.

in Journal of Biological Chemistry (2003), 278(34), 31972-9

See detailPrinciples of interleukin (IL)-6-type cytokine signalling and its regulation
Heinrich, P. C.; Behrmann, Iris; Haan, Serge; Hermanns, H. M.; Müller-Newen, G.; Schaper, F.

in Biochemical Journal (2003), 374(Pt 1), 1-20

See detailFusionierte lösliche Rezeptoren als hochaktive Zytokin-Inhibitoren.
Müller-Newen, Gerhard; Haan, Serge; Heinrich, Peter C.

in Biospektrum (2003), Sonderausgabe(9. Jahrgang), 480-483

See detailActivation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
Niemand, Claudia; Nimmesgern, Ariane; Haan, Serge; Fischer, Patrick; Schaper, Fred; Rossaint, Rolf; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of immunology (Baltimore, Md. : 1950) (2003), 170(6), 3263-72

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2002

See detailA new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M.; Heinrich, Peter C.; Haan, Serge

in European Journal of Biochemistry (2002), 269(10), 2516-26

See detailSuppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M.; Johnston, James A.; Heinrich, Peter C.; Haan, Serge

in Journal of immunology (Baltimore, Md. : 1950) (2002), 169(3), 1219-27

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2000

See detailCytoplasmic STAT proteins associate prior to activation
Haan, Serge; Kortylewski, M.; Behrmann, Iris; Müller-Esterl, W.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2000), 345 Pt 3

See detailSOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
Schmitz, J.; Weissenbach, M.; Haan, Serge; Heinrich, P. C.; Schaper, F.

in Journal of Biological Chemistry (2000), 275(17), 12848-56

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1999

See detailCharacterization and binding specificity of the monomeric STAT3-SH2 domain.
Haan, Serge; Hemmann, U.; Hassiepen, U.; Schaper, F.; Schneider-Mergener, J.; Wollmer, A.; Heinrich, P. C.; Grotzinger, J.

in Journal of Biological Chemistry (1999), 274(3), 1342-8

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