Publications

2018

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See detailSecretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9.
Schenten, Veronique; Plancon, Sebastien; Jung, Nicolas; Hann, Justine; Bueb, Jean-Luc; Bréchard, Sabrina; Tschirhart, Eric; Tolle, Fabrice

in Frontiers in immunology (2018), 9

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2015

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See detailEffects of Endocrine Disruptor Compounds, Alone or in Combination, on Human Macrophage-Like THP-1 Cell Response
Couleau, Nicolas; Falla, Jairo; Beillerot, Adeline; Battaglia, Eric; d’Innocenzo, Marielle; Plançon, Sébastien; Laval-Gilly, Philippe; Bennasroune, Amar

in PLoS ONE (2015), 10(7), 0131428

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See detailRole of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells
Dorosz, Susann Antonia; Ginolhac, Aurélien; Kähne, Thilo; Naumann, Michael; Sauter, Thomas; Salsmann, Alexandre; Bueb, Jean-Luc

in Mediators of Inflammation (2015), 2015

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See detailInsights from ENCODE on Missing Proteins: Why beta-Defensin Expression Is Scarcely Detected.
Fan, Yang; Zhang, Yue; Xu, Shaohang; Kong, Nannan; Zhou, Yang; Ren, Zhe; Deng, Yamei; Lin, Liang; Ren, Yan; Wang, Quanhui; Zi, Jin; Wen, Bo; Liu, Siqi

in Journal of proteome research (2015), 14(9), 3635-44

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See detailAssessing Transcription Regulatory Elements To Evaluate the Expression Status of Missing Protein Genes on Chromosomes 11 and 19.
Kong, Nannan; Zhou, Yang; Xu, Shaohang; Deng, Yamei; Fan, Yang; Zhang, Yue; Ren, Zhe; Lin, Liang; Ren, Yan; Wang, Quanhui; Zi, Jin; Wen, Bo; Liu, Siqi

in Journal of proteome research (2015), 14(12), 4967-75

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See detailHind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging
Lescale, Chloé; Schenten, Véronique; Djeghloul, Dounia; Bennabi, Meriem; Gaignier, Fanny; Vandamme, Katleen; Strazielle, Catherine; Kuzniak, Isabelle; Petite, Hervé; Dosquet, Christine; Frippiat, Jean-Pol; Goodhardt, Michèle

in FASEB Journal (2015), 29(2), 455-63

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See detailRegulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting
Naegelen, Isabelle; Beaume, Nicolas; Plançon, Sébastien; Schenten, Véronique; Tschirhart, Eric; Bréchard, Sabrina

in Journal of Immunology Research (2015), 2015

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See detailIntegrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network
Pacheco, Maria; John, Elisabeth; Kaoma, Tony; Heinäniemi, Merja; Nicot, Nathalie; Vallar, Laurent; Bueb, Jean-Luc; Sinkkonen, Lasse; Sauter, Thomas

in BMC Genomics (2015), 16(809),

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2014

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See detailFibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma
Gauglhofer, Christine; Paur, Jakob; Schrottmaier, Waltraud C.; Wingelhofer, Bettina; Huber, Daniela; Naegelen, Isabelle; Pirker, Christine; Mohr, Thomas; Heinzle, Christine; Holzmann, Klaus; Marian, Brigitte; Schulte-Hermann, Rolf; Berger, Walter; Krupitza, Georg; Grusch, Michael; Grasl-Kraupp, Bettina

in Carcinogenesis (2014), 35(10), 2331-2338

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See detailAn essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells
Naegelen, Isabelle; Plançon, Sébastien; Nicot, Nathalie; Kaoma, Tony; Muller, Arnaud; Vallar, Laurent; Tschirhart, Eric; Bréchard, Sabrina

in Journal of Leukocyte Biology (2014), 97

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2013

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See detailNew Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling
Bréchard, Sabrina; Plançon, Sébastien; Tschirhart, Eric

in Antioxidants & Redox Signaling (2013), 18(6), 661-676

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See detailThe recruitment of p47 and Rac2G12V at the phagosome is transient and phosphatidylserine dependent.
Faure, Marie Cecile; Sulpice, Jean-Claude; Delattre, Maud; Lavielle, Marc; Prigent, Magali; Cuif, Marie-Helene; Melchior, Chantal; Tschirhart, Eric; Nusse, Oliver; Dupre-Crochet, Sophie

in Biology of the Cell (2013)

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See detailGravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis
Huin-Schohn, Cécile; Gueguinou, Nathan; Schenten, Véronique; Bascove, Matthieu; Koch, Guillemette Gauquelin; Baatout, Sarah; Tschirhart, Eric; Frippiat, Jean-Pol

in FASEB Journal (2013), 27(1), 333-341

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2012

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See detailRole of the Neutrophil NADPH Oxidase and S100A8/A9 in the Pathophysiology of Chronic Inflammation
Bréchard, Sabrina; Schenten, Véronique; Tschirhart, Eric

in Khatami, Mahin (Ed.) Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases (2012)

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See detailStress response and humoral immune system alterations related to chronic hypergravity in mice
Gueguinou, Nathan; Bojados, Mickael; Jamon, Marc; Derradji, Hanane; Baatout, Sarah; Tschirhart, Eric; Frippiat, Jean-Pol; Legrand-Frossi, Christine

in Psychoneuroendocrinology (2012), 37(1), 137-147

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2011

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See detailSphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9
Schenten, Véronique; Melchior, Chantal; Steinckwich, Nathalie; Tschirhart, Eric; Bréchard, Sabrina

in Journal of Leukocyte Biology (2011), 89(4), 587-596

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See detailAn essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity
Steinckwich, Natacha; Schenten, Véronique; Melchior, Chantal; Bréchard, Sabrina; Tschirhart, Eric

in Journal of Immunology (2011), 186(4), 2182-2191

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2010

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See detailNew biological investigations on 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate as anti-angiogenic agent
Hemmer, Marc; Kempen, Isabelle; de Tullio, Pascal; Frankenne, Francis; Lambert, Vincent; Blacher, Silvia; Bueb, Jean-Luc; Foidart, Jean-Michel; Noël, Agnès; Tschirhart, Eric; Pirotte, Bernard

in Drug Development Research (2010), 71

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See detailiPLA 2 , a novel determinant in Ca2+ - and phosphorylation-dependent S100A8/A9 regulated NOX2 activity
Schenten, Véronique; Bréchard, Sabrina; Plançon, Sébastien; Melchior, Chantal; Frippiat, Jean-Pol; Tschirhart, Eric

in Biochimica et Biophysica Acta-Molecular Cell Research (2010), 1803(7), 840-847

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2009

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See detailSpaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl
Bascove, Matthieu; Huin-Schohn, Cécile; Gueguinou, Nathan; Tschirhart, Eric; Frippiat, Jean-Pol

in FASEB Journal (2009), 23(5), 1607-1615

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See detailSTIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells
Bréchard, Sabrina; Plançon, Sébastien; Melchior, Chantal; Tschirhart, Eric

in Biochemical Pharmacology (2009), 78(5), 504-513

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See detailOAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca 2+ entry
Bréchard, Sabrina; Salsmann, Alexandre; Tschirhart, Eric

in Journal of Leukocyte Biology (2009), 85(4), 638-647

See detailTransmissions cholinergiques
Bueb, Jean-Luc

in Landry, Yves; Gies, Jean-Pierre (Eds.) Pharmacologie. Des cibles vers l’indication thérapeutique (2009)

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See detailCould spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit?
Gueguinou, Nathan; Huin-Schohn, Cécile; Bascove, Matthieu; Bueb, Jean-Luc; Tschirhart, Eric; Legrand-Frossi, Christine; Frippiat, Jean-Pol

in Journal of Leukocyte Biology (2009), 86(5), 1027-1038

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See detailOverexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells
Schaffner-Reckinger, Elisabeth; Salsmann, Alexandre; Debili, Najet; Bellis, Julien; De Mey, Jan; Vainchenker, William; Ouwehand, Willem H.; Kieffer, Nelly

in Journal of Thrombosis and Haemostasis [=JTH] (2009), 7(7), 1207-1217

See detailLes peptides opioïdes et autres médiateurs de la nociception
Tschirhart, Eric

in Landry, Yves; Gies, Jean-Pierre (Eds.) Pharmacologie. Des cibles vers l’indication thérapeutique (2009)

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2008

See detailCell passaging rapidly affects expression, secretion and activity of MMP9 as well as mobility of HL60 leukemia cells
Bernard, Yohann; Plançon, Sébastien; Melchior, Chantal; Tschirhart, Eric; Bueb, Jean-Luc

in Journal of Cell and Animal Biology (2008), 2(9), 160-165

See detailStore-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes
Bréchard, Sabrina; Melchior, Chantal; Plançon, Sébastien; Schenten, Véronique; Tschirhart, Eric

in Cell Calcium (2008)

See detailRegulation of superoxide production in neutrophils: role of calcium influx
Bréchard, Sabrina; Tschirhart, Eric

in Journal of Leukocyte Biology (2008), 84(5), 1223-1237

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See detailA nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the αIIbβ3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
Ghevaert, Cedric; Salsmann, Alexandre; Watkins, Nicholas A.; Schaffner-Reckinger, Elisabeth; Rankin, Angela; Garner, Stephen F.; Stephens, Jonathan; Smith, Graham A.; Debili, Najet; Vainchenker, William; de Groot, Philip G.; Huntington, James A.; Laffan, Mike; Kieffer, Nelly; Ouwehand, Willem H.

in Blood (2008), 111(7), 3407-3414

See detailCa2+-dependent regulation of NOX2 activity via MRP proteins in HL-60 granulocytes
Schenten, Véronique; Bréchard, Sabrina; Melchior, Chantal; Plançon, Sébastien; Salsmann, Alexandre; Tschirhart, Eric

in Calcium Binding Proteins (2008), 3(1), 25-30

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2006

See detailModulation by cADPr of Ca2+ mobilization and oxidative response in dimethylsulfoxide- or retinoic acid-differentiated HL-60 cells
Bréchard, Sabrina; Brunello, A.; Bueb, Jean-Luc; Tschirhart, Eric

in Biochimica et Biophysica Acta (2006), 1763(1), 129-36

See detailRosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway
Otto, A.; Fontaine, J.; Tschirhart, Eric; Fontaine, D.; Berkenboom, G.

in British Journal of Pharmacology (2006), 148(4), 544-52

See detailRGD, the Rho'd to cell spreading
Salsmann, Alexandre; Schaffner-Reckinger, Elisabeth; Kieffer, Nelly

in European Journal of Cell Biology (2006), 85(3-4), 249-254

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2005

See detailInterleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium
Bréchard, Sabrina; Bueb, Jean-Luc; Tschirhart, Eric

in Cell Calcium (2005), 37(6), 531-40

See detailThe Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop
Gennari, Alessandra; Ban, Masarin; Braun, Armin; Casati, Silvia; Corsini, Emanuela; Dastych, Jaroslaw; Descotes, Jacques; Hartung, Thomas; Hooghe-Peters, Robert; House, Robert; Pallardy, Marc; Pieters, Raymond; Reid, Lynnda; Tryphonas, Helen; Tschirhart, Eric; Tuschl, Helga; Vandebriel, Rob; Gribaldo, Laura

in Journal of Immunotoxicology (2005), 2(2), 61-83

See detailA new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin alphaIIbbeta3-dependent RhoA activation during cell spreading
Salsmann, Alexandre; Schaffner-Reckinger, Elisabeth; Kabile, Fabrice; Plançon, Sébastien; Kieffer, Nelly

in Journal of Biological Chemistry (2005), 280(39), 33610-33619

See detailOxidative stress activates MMP-2 in cultured human coronary smooth muscle cells
Valentin, F.; Bueb, Jean-Luc; Kieffer, P.; Tschirhart, Eric; Atkinson, J.

in Fundamental & Clinical Pharmacology (2005), 19(6), 661-7

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2004

See detailA fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain
Tremuth, L. A; Kreis, Stephanie; Melchior, C. A; Hoebeke, J. B; Rondé, P. C D; Plançon, Sébastien; Takeda, K. C; Kieffer, N. A

in Journal of Biological Chemistry (2004), 279(21), 22258-22266

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