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Molecular & Functional Neurobiology Group

The Molecular & Functional Neurobiology group at the LCSB

First row (from left to right): Semra Smajic, Dr. Sylvie Delcambre, Jenny Ghelfi, Dr. Dajana Grossmann

Second row (from left to right): Kobi Wasner, Katja Badanjak, Nassima Ouzren, Dr. Anne Grünewald, Patrycja Mulica, Dr. Sandro Pereir

About the Molecular & Functional Neurobiology Group

The Molecular & Functional Neurobiology Group employs molecular, ‘omics’ and single-cell approaches to decipher the genetic and non-genetic origins of Parkinson’s disease (PD). We explore the role of the mitochondrial genome in the pathogenesis of idiopathic PD (IPD) using post-mortem and iPSC-derived tissues. We aim to identify novel cellular pathways, which may be targets for therapeutic intervention in the future. With regard to genetic PD, we are particularly interested in reduced penetrance, i.e. the phenomenon that despite the presence of a disease-causing variant, some individuals will never develop any signs of PD. Here, we aim to uncover disease progression markers as well as molecular mechanisms that can be modulated by drugs to delay the onset of PD.

The Molecular and Functional Neurobiology group was established under the auspices of the Luxembourg National Research Fund's ATTRACT Programme.