Publications
2022
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature metabolism (2022), 4(5), 589-607
An archaeal compound as a driver of Parkinson’s disease pathogenesis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2022)
Regulation of N6-Methyladenosine after Myocardial Infarction; ; ; ; ; ; ; ; ; ;
in Cells (2022), 11(15), 2271
2021
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science Advances (2021), 7(42),
Approaches for completing metabolic networks through metabolite damage and repair discovery; ;
in Current Opinion in Systems Biology (2021), 28
The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2021)
The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease; ; ; ; ;
in Cells (2021)
2020
L-Isoaspartyl methyltransferase deficiency in zebrafish leads to impaired calcium signaling in the brain; ; ; ; ; ; ; ; ;
in Frontiers in Genetics (2020)
Reply: NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illness; ;
in Brain: a Journal of Neurology (2020), 143(7), 55
2019
Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency; ; ; ;
in Brain Communications (2019), 1(1), 2-17
Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges; ; ; ; ; ; ; ; ; ;
in Environmental Science. Processes and Impacts (2019)
NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain: a Journal of Neurology (2019), 142(1), 50-58
Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2019), 116(4), 1241-1250
BSA4Yeast: Web-based quantitative trait locus linkage analysis and bulk segregant analysis of yeast sequencing data; ; ; ; ;
in GigaScience (2019), 8(6), 060
2018
NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells; ; ; ; ; ; ;
in FEBS Journal (2018)
Millifluidic culture improves human midbrain organoid vitality and differentiation; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2018)
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control; ; ; ; ; ;
in npj Aging and Mechanisms of Disease (2018), 4(3),
2017
Confronting the catalytic dark matter encoded by sequenced genomes; ; ; ;
in Nucleic Acids Research (2017), 45(20), 11495-11514
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017), 1613736114
Elucidation of new enzyme function using yeast, comparative genomics and metabolomicsDoctoral thesis (2017)
Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals; ;
in Journal of Biological Chemistry (2017), 292(3), 1005-1028
2016
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.; ; ; ; ; ;
in The Journal of Biological Chemistry (2016)
A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Chemical Biology (2016), 12(8), 601-607
2015
Protocols and programs for high-throughput growth and aging phenotyping in yeast.; ; ; ;
in PloS one (2015), 10(3), 0119807
Enzyme complexity in intermediary metabolism.; ;
in Journal of inherited metabolic disease (2015), 38(4), 721-7
2014
Occurrence and subcellular distribution of the NAD(P)HX repair system in mammals.; ; ; ; ;
in The Biochemical journal (2014), 460(1), 49-58
2013
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2013)
Metabolite proofreading, a neglected aspect of intermediary metabolism; ; ; ; ;
in Journal of Inherited Metabolic Disease (2013), 36(3), 427-34
2012
Impact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-L-galactose phosphorylase; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2012), 287(17), 14234-45
2011
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals; ; ;
in Journal of Biological Chemistry (2011), 286(24), 21511-23
Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading; ; ; ; ; ; ;
in Journal of Biological Chemistry (2011), 286(50), 42992-3003
Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair; ; ; ; ;
in Journal of Biological Chemistry (2011), 286(48), 41246-52
2009
Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans; ; ;
in Mechanisms of Ageing and Development (2009), 130(10), 670-80
