Dr. Christian Jäger
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| Faculté ou Centre | Luxembourg Centre for Systems Biomedicine | ||||
| Department | Scientific Central Services | ||||
| Adresse postale |
Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Bureau sur le campus | BioTech II, 1.21 | ||||
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| Téléphone | (+352) 46 66 44 6650 | ||||
Metabolomics Platform Manager in the Enzymology & Metabolism group (Linster Lab)
Last updated on: lundi 05 décembre 2016
2022
An archaeal compound as a driver of Parkinson’s disease pathogenesis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2022)
Regulation of N6-Methyladenosine after Myocardial Infarction; ; ; ; ; ; ; ; ; ;
in Cells (2022), 11(15), 2271
2021
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science Advances (2021), 7(42),
Systematic characterization of human gut microbiome-secreted molecules by integrated multi-omics; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ISME Communications (2021)
Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2021)
2020
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Acta Neuropathologica Communications (2020)
GBA variants in Parkinson’s disease: clinical, metabolomic and multimodal neuroimaging phenotypes; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2020), 35(12), 2201-2210
Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Communications (2020)
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Metabolism (2020), 31(5), 920--9367
2019
Metabolite profiling of the cold adaptation of Pseudomonas putida KT2440 and cold‐sensitive mutants; ; ; ;
in Environmental Microbiology Reports (2019)
Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease; ; ; ; ; ; ; ; ;
in Neurobiology of Disease (2019), 124(1), 555-562
Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2019)
2018
Combining PET imaging and blood metabolomics data to improve machine learning models for Parkinson’s disease diagnosis; ; ; ; ; ; ; ;
Poster (2018, October 08)
Integrated time-resolved multi-omics for understanding microbial niche ecology; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Poster (2018, August)
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control; ; ; ; ; ;
in npj Aging and Mechanisms of Disease (2018), 4(3),
Quantification of Stable Isotope Traces Close to Natural Enrichment in Human Plasma Metabolites Using Gas Chromatography-Mass Spectrometry; ; ; ;
in Metabolites (2018), 8(1), 15
Itaconic acid indicates cellular but not systemic immune system activation; ; ; ; ; ; ;
in Oncotarget (2018), 9(63),
Combining Metabolomics and Neuroimaging in mid-stage Parkinson’s Disease. A Proof of Concept for Cross-Fertilization.; ; ; ; ; ; ;
in Neurology (2018), 90(15), 3066
2017
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017)
Glutathione Primes T Cell Metabolism for Inflammation; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Immunity (2017), 46(4), 675-689
Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease: Early Parkinson'S CSF Metabolic Signature; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2017)
Metabolic profiling of body fluids and multivariate data analysis; ; ; ; ; ;
in MethodsX (2017), 4(1), 95-103
2016
A study of the molecular mechanisms underlying the response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics; ; ; ; ; ; ; ; ; ;
Poster (2016, June)
Metabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography-Mass Spectrometry: Metabolic Profiling of Neurotransmitters by GC-MS; ;
in Auwerx, Johan; Ackerman, Susan L.; Brown, Stephen D.; Justice, Monica J.; Nadeau, Joseph (Eds.) Current Protocols in Mouse Biology (2016)
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Metabolic Engineering (2016)
Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota; ; ; ; ; ; ; ; ; ; ;
in Nature Biotechnology (2016)
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Disease (2016), 89
A microfluidics-based in vitro model of the gastrointestinal human-microbe interface.; ; ; ; ; ; ; ; ; ; ;
in Nature communications (2016), 7
Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions; ; ; ; ; ; ;
in Cell Reports (2016), 16(6), 1536--1547
2015
The neural stem cell fate determinant TRIM32 regulates complex behavioral traits; ; ; ; ; ; ;
in Frontiers in Cellular Neuroscience (2015)
The Mouse Brain Metabolome: Region-Specific Signatures and Response to Excitotoxic Neuronal Injury; ; ; ; ; ; ; ; ;
in American Journal of Pathology (2015), 185(6), 1699-1712
Isotopologue ratio normalization for non-targeted metabolomics; ; ;
in Journal of Chromatography. A (2015), 1389
2014
Fragment Formula Calculator (FFC): Determination of chemical formulas for fragment ions in mass spectrometric data; ; ; ; ; ;
in Analytical Chemistry (2014), 86(4), 22212228
2012
The metabolic response of P. putida KT2442 producing high levels of polyhydroxyalkanoate under single-and multiple-nutrient-limited growth: Highlights from a multi-level omics approach; ; ; ; ; ; ;
in Microbial Cell Factories (2012)
2009
MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis; ; ; ; ;
in Analytical Chemistry (2009)
