Page d'accueil // LCSB // Research // Parkinson's disease map

Parkinson's disease map

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world. Although many genetic and environmental factors contributing to the risk of PD have been identified, no unique causal mechanism is defined.


Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. To that end, LCSB, in the collaboration with the Systems Biology Institute, Tokyo (SBI), has developed the Parkinson’s disease (PD) map (Fujita et al.).



The PD map is a manually curated knowledge repository established to describe molecular mechanisms of PD. It compiles literature-based information on PD into an easy to explore and freely accessible molecular interaction map and offers research-facilitating functionalities such as the overlay of experimental data and the identification of drug targets on the map (see user guide).

We envision the PD map as a hub for the PD community to deal with the exponentially increasing information on PD and we encourage the PD community to join forces and support this project by integrating their expertise to continuously refine and expand the knowledge within the PD map (see community).

With our continuous efforts in developing the computational tools and the joint curation of content with the PD community, we hope that thefreely accessible PD map opens new avenues in PD research.

To get newest information on PD map, please subscribe for the PD map newsletter.


“Decoding Parkinson’s”: an article about the PD map

The PD map was recently covered in an article on the web portal Undark, covering topics intersecting science and society. Take a look what they write about us!



MINERVA 12.2 release

We are happy to announce the new release of MINERVA platform, which hosts the PD map.

PD map update - February '19 edition

We are happy to release our new edition of the PD map. We've added over 40 new publications and updated over 100 interactions!

PD map update – April’18 edition

We are happy to release our new edition of the PD map. We have added over 80 new publications and updated over 160 interactions. Postsynaptic area and projections to other brain regions, and the dopaminergic transcription were greatly enriched. Take a look!

PD map update - September '17 edition

We are proud to announce a new release of the Parkinson's disease map. This PD map update brings changes in the user interface and the improvement of many functionalities.

  • First curation workshop in Geneva, 2013
  • The hallmarks of Parkinson's disease
  • The PD map at the Bremen Expo, 2013
  • An early version of the PD map      </p>

  • Parkinson's disease puzzle