Dr. Lisa Smits


Faculté ou Centre Luxembourg Centre for Systems Biomedicine
Department LCSB Operations
Adresse postale Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Bureau sur le campus BioTech II, 2.07
Téléphone (+352) 46 66 44 6038

Lisa started her first research project at the LCSB in 2014. After obtaining her PhD in Neurobiology, she joined the LCSB administrative staff to support the communication team. Today, she is part of the university's Fundraising Office and acts as a Fundraiser for the LCSB.

Last updated on: vendredi 17 janvier 2020

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See detailMidbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression
Zagare, Alise; Barmpa, Kyriaki; Smajic, Semra; Smits, Lisa; Grzyb, Kamil; Grünewald, Anne; Skupin, Alexander; Nickels, Sarah Louise; Schwamborn, Jens Christian

in American Journal of Human Genetics (2022)

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See detailA new brain organoid model to study Parkinson’s Disease
Bolognin, Silvia; Smits, Lisa; Nickels, Sarah Louise; Magni, Stefano; Antony, Paul; Grzyb, Kamil; Krüger, Rejko; Skupin, Alexander; Schwamborn, Jens Christian

in Biomedical Science and Engineering (2021)

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See detailParkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment
Jarazo, Javier; Barmpa, Kyriaki; Modamio, Jennifer; Saraiva, Claudia; Sabaté Soler, Sonia; Rosety, Isabel; Griesbeck, Anne; Skwirblies, Florian; Zaffaroni, Gaia; Smits, Lisa; Su, Jihui; Arias-Fuenzalida; Walter, Jonas; Gomez Giro, Gemma; Monzel, Anna; Qing, Xiaobing; Vitali, Armelle; Cruciani, Gérald; Boussaad, Ibrahim; Brunelli, Francesco; Jäger, Christian; Rakovic, Aleksandar; Wen, Li; Yuan, Lin; Berger, Emanuel; Arena, Giuseppe; Bolognin, Silvia; Schmidt, Ronny; Schröder, Christoph; Antony, Paul; Klein, Christine; Krüger, Rejko; Seibler, Philip; Schwamborn, Jens Christian

in Movement Disorders (2021)

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See detailThe Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
Walter, Jonas; Bolognin, Silvia; Poovathingal, Suresh; Magni, Stefano; Gerard, Déborah; Antony, Paul; Nickels, Sarah Louise; Salamanca, Luis; Berger, Emanuel; Smits, Lisa; Grzyb, Kamil; Perfeito, Rita; Hoel, Fredrik; Qing, Xiaobing; Ohnmacht, Jochen; Bertacchi, Michele; Jarazo, Javier; Ignac, Tomasz; Monzel, Anna; Gonzalez-Cano, Laura; Krüger, Rejko; Sauter, Thomas; Studer, Michele; Pereira de Almeida, Luis; Tronstad, Karl; Sinkkonen, Lasse; Skupin, Alexander; Schwamborn, Jens Christian

in Cell Reports (2021)

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See detailMonitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson’s disease modeling and drug screening.
Zanetti, Cristian; Spitz, Sarah; Berger, Emanuel; Bolognin, Silvia; Smits, Lisa; Crepaz, Philipp; Rothbauer, Mario; Rosser, Julie M; Marchetti'Deschmann, Martina; Schwamborn, Jens Christian; Ertl, Peter

in Analyst (2021)

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See detailMachine learning-assisted neurotoxicity prediction in human midbrain organoids
Monzel, Anna Sophia; Hemmer, K; Smits, Lisa; Bolognin, Silvia; Lucarelli, P; Rosety, Isabel; Zagare, Alise; Antony, Paul; Nickels, SL; Krüger, Rejko; Schwamborn, Jens Christian

in Parkinsonism and Related Disorders (2020)

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See detailSingle-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids
Smits, Lisa; Magni, Stefano; Kinugawa, Kaoru; Grzyb, Kamil; Luginbühl, Joachim; Sabaté Soler, Sonia; Bolognin, Silvia; Shin, Jay; Mori, Eiichiro; Skupin, Alexander; Schwamborn, Jens Christian

in Cell and Tissue Research (2020)

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See detailMidbrain organoids: A new tool to investigate Parkinson's disease
Smits, Lisa; Schwamborn, Jens Christian

in Frontiers in Cell and Developmental Biology (2020)

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See detailSingle-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids
Smits, Lisa; Magni, Stefano; Grzyb, Kamil; Antony, Paul; Krüger, Rejko; Skupin, Alexander; Bolognin, Silvia; Schwamborn, Jens Christian

E-print/Working paper (2019)

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See detailModeling Parkinson’s disease in midbrain-like organoids
Smits, Lisa; Reinhardt, Lydia; Reinhardt, Peter; Glatza, Michael; Monzel, Anna Sophia; Stanslowsky, Nancy; Rosato-Siri, Marcelo; Zanon, Alessandra; Antony, Paul; Bellmann, Jessica; Nicklas, Sarah; Hemmer, Kathrin; Qing, Xiaobing; Berger, Emanuel; Kalmbach, Norman; Ehrlich, Marc; Bolognin, Silvia; Hicks, Andrew; Wegner, Florian; Sterneckert, Jared; Schwamborn, Jens Christian

in NPJ Parkinson's Disease (2019)

See detailCultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips
Spitz, Sarah; Zanetti, Cristian; Bolognin, Silvia; Muwanigwa, Mudiwa Nathasia; Smits, Lisa; Berger, Emanuel; Jordan, Christian; Harasek, Michael; Schwamborn, Jens Christian; Ertl, Peter

E-print/Working paper (2019)

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See detailIn vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading
Hemmer, Kathrin; Smits, Lisa; Bolognin, Silvia; Schwamborn, Jens Christian

in Opera Medica et Physiologica (2018)

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See detailActivity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity
Jan, Asad; Jansonius, Brandon; Delaidelli, Alberto; Bhanshali, Forum; An, Yi Andy; Ferreira, Nelson; Smits, Lisa; Negri, Gian Luca; Schwamborn, Jens Christian; Jensen, Poul; Mackenzie, Ian; Taubert, Stefan; Sorensen, Poul

in Acta Neuropathologica Communications (2018)

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See detailIn Vivo Phenotyping Of Parkinson-Specific Stem Cells Reveals Increased a-Synuclein Levels But No Spreading
Hemmer, Kathrin; Smits, Lisa; Bolognin, Silvia; Schwamborn, Jens Christian

in bioRxiv (2017)

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See detailDerivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Monzel, Anna Sophia; Smits, Lisa; Hemmer, Kathrin; Hachi, Siham; Lucumi Moreno, Edinson; Van Wüllen, Thea Maria; Jarazo, Javier; Walter, Jonas; Werthschulte, Inga; Boussaad, Ibrahim; Berger, Emanuel; Fleming, Ronan MT; Bolognin, Silvia; Schwamborn, Jens Christian

in Stem Cell Reports (2017)

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See detailNurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease
Spathis, Athanasios; Asvos, Xenophon; Ziavra, Despina; Karampelas, Theodoros; Topouzis, Stavros; Cournia, Zoe; Qing, Xiaobing; Alexakos, Pavlos; Smits, Lisa; Dalla, Christina; Rideout, Hardy; Schwamborn, Jens Christian; Tamvakopoulos, Constantin; Fokas, Demosthenes; Vassilatis, Demetrios

in Proceedings of the National Academy of Sciences of the United States of America (2017)

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