Evan Williams
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| Faculté ou Centre | Luxembourg Centre for Systems Biomedicine | ||||
| Department | Gene Expression and Metabolism | ||||
| Adresse postale |
Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Bureau sur le campus | BioTech II Ketterthill, 5.15 | ||||
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| Téléphone | (+352) 46 66 44 5088 | ||||
Principal Investigator of the Gene Expression & Metabolism group (Williams lab)
Last updated on: mardi 29 septembre 2020
2022
GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Cell Biology (2022), 221(2),
Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Metabolism (2022), 34(10), 1594-1610
The mouse metallomic landscape of aging and metabolism; ; ; ; ; ; ;
in Nature Communications (2022), 13(607),
PCfun: a hybrid computational framework for systematic characterization of protein complex function; ; ; ; ; ; ; ; ; ; ; ; ;
in Briefings in Bioinformatics (2022), 23(4), 239
Multiomic profiling of the liver across diets and age in a diverse mouse population; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Systems (2022), 13(1), 43-57
2021
A platform for experimental precision medicine: The extended BXD mouse family.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell systems (2021), 12(3), 235-2479
Diagnostics and correction of batch effects in large-scale proteomic studies: a tutorial.; ; ; ; ; ; ; ; ; ; ; ;
in Molecular systems biology (2021), 17(8), 10240
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Metabolism (2021)
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports Medicine (2021), 2(4), 100226
2020
Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30.; ; ; ; ; ; ; ; ; ; ; ; ;
in The Journal of cell biology (2020), 219(6),
A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell metabolism (2020), 31(3), 549-5637
SECAT: Quantifying Protein Complex Dynamics across Cell States by Network-Centric Analysis of SEC-SWATH-MS Profiles.; ; ; ; ; ; ; ; ;
in Cell systems (2020), 11(6), 589-6078
Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family.; ; ; ; ; ;
in Aging cell (2020), 19(9), 13207
2019
Mild inborn errors of metabolism in commonly used inbred mouse strains.; ; ; ; ; ; ; ; ; ; ;
in Molecular Genetics and Metabolism (2019), 126(4), 388-396
Multi-omic measurements of heterogeneity in HeLa cells across laboratories.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature biotechnology (2019), 37(3), 314-322
Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population.; ; ; ; ; ;
in PloS one (2019), 14(10), 0224100
A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model.; ; ; ; ; ; ; ; ; ; ;
in Scientific reports (2019), 9(1), 6913
JCAD: from systems genetics identification to the experimental validation of a coronary artery disease risk locus.;
in European heart journal (2019), 40(29), 2409-2412
2018
Genetic cartography of longevity in humans and mice: Current landscape and horizons.; ; ; ; ; ; ; ;
in Biochimica et biophysica acta. Molecular basis of disease (2018), 1864(9 Pt A), 2718-2732
Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.; ; ; ; ; ; ; ; ; ; ; ;
in Cell systems (2018), 6(6), 722-7336
Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell systems (2018), 6(6), 709-7216
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell reports (2018), 23(9), 2819-28315
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population.; ; ; ; ; ; ; ; ; ;
in Molecular and Cellular Proteomics (2018), 17(9), 1766-1777
2017
Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature communications (2017), 8(1), 1212
Application of SWATH Proteomics to Mouse Biology.; ;
in Current protocols in mouse biology (2017), 7(2), 130-143
2016
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell (2016), 165(5), 1209-1223
The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms.; ; ; ; ; ; ; ; ; ; ;
in Current protocols in neuroscience (2016), 77
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature medicine (2016), 22(8), 879-88
Joint mouse-human phenome-wide association to test gene function and disease risk.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature communications (2016), 7
Systems proteomics of liver mitochondria function.; ; ; ; ; ; ; ; ; ; ;
in Science (2016), 352(6291), 0189
2015
Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.; ; ; ; ; ; ; ; ; ; ;
in Cell reports (2015), 10(10), 1681-1691
Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Diabetes (2015), 64(4), 1193-201
The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis.;
in Cell (2015), 162(1), 23-32
2014
Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers.; ; ; ; ;
in Cell metabolism (2014), 19(1), 84-95
Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell metabolism (2014), 19(6), 1034-41
An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement.; ; ; ; ; ;
in PLoS genetics (2014), 10(9), 1004673
Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population.; ; ; ; ; ; ; ; ; ; ; ;
in Cell (2014), 158(6), 1415-1430
2012
Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.; ; ; ; ; ; ; ;
in Cell (2012), 150(6), 1287-99
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits.; ; ; ; ; ; ; ; ; ; ; ; ;
in PloS one (2012), 7(6), 39191
2011
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.; ; ; ; ; ; ; ; ; ; ;
in Cell (2011), 147(4), 827-39
