Dr. Carole Linster
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| Faculté ou Centre | Luxembourg Centre for Systems Biomedicine | ||||
| Department | Enzymology and Metabolism | ||||
| Adresse postale |
Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Bureau sur le campus | BioTech II, 1.17 | ||||
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| Téléphone | (+352) 46 66 44 6231 | ||||
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Associate Prof. Dr. Carole Linster (LCSB)
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Principal Investigator in the Enzymology & Metabolism group (Linster Lab)
Last updated on: mercredi 05 août 2015
2022
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature metabolism (2022), 4(5), 589-607
An archaeal compound as a driver of Parkinson’s disease pathogenesis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2022)
Regulation of N6-Methyladenosine after Myocardial Infarction; ; ; ; ; ; ; ; ; ;
in Cells (2022), 11(15), 2271
2021
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science Advances (2021), 7(42),
Approaches for completing metabolic networks through metabolite damage and repair discovery; ;
in Current Opinion in Systems Biology (2021), 28
The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2021)
The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease; ; ; ; ;
in Cells (2021)
2020
L-Isoaspartyl methyltransferase deficiency in zebrafish leads to impaired calcium signaling in the brain; ; ; ; ; ; ; ; ;
in Frontiers in Genetics (2020)
Reply: NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illness; ;
in Brain: a Journal of Neurology (2020), 143(7), 55
2019
Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency; ; ; ;
in Brain Communications (2019), 1(1), 2-17
Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges; ; ; ; ; ; ; ; ; ;
in Environmental Science. Processes and Impacts (2019)
NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain: a Journal of Neurology (2019), 142(1), 50-58
Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2019), 116(4), 1241-1250
BSA4Yeast: Web-based quantitative trait locus linkage analysis and bulk segregant analysis of yeast sequencing data; ; ; ; ;
in GigaScience (2019), 8(6), 060
2018
NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells; ; ; ; ; ; ;
in FEBS Journal (2018)
Millifluidic culture improves human midbrain organoid vitality and differentiation; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2018)
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control; ; ; ; ; ;
in npj Aging and Mechanisms of Disease (2018), 4(3),
2017
Confronting the catalytic dark matter encoded by sequenced genomes; ; ; ;
in Nucleic Acids Research (2017), 45(20), 11495-11514
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017), 1613736114
Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals; ;
in Journal of Biological Chemistry (2017), 292(3), 1005-1028
2016
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.; ; ; ; ; ;
in The Journal of Biological Chemistry (2016)
A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Chemical Biology (2016), 12(8), 601-607
2015
Protocols and programs for high-throughput growth and aging phenotyping in yeast.; ; ; ;
in PloS one (2015), 10(3), 0119807
Enzyme complexity in intermediary metabolism.; ;
in Journal of inherited metabolic disease (2015), 38(4), 721-7
2014
Occurrence and subcellular distribution of the NAD(P)HX repair system in mammals.; ; ; ; ;
in The Biochemical journal (2014), 460(1), 49-58
2013
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2013)
Metabolite proofreading, a neglected aspect of intermediary metabolism; ; ; ; ;
in Journal of Inherited Metabolic Disease (2013), 36(3), 427-34
2012
Impact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-L-galactose phosphorylase; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2012), 287(17), 14234-45
2011
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals; ; ;
in Journal of Biological Chemistry (2011), 286(24), 21511-23
Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading; ; ; ; ; ; ;
in Journal of Biological Chemistry (2011), 286(50), 42992-3003
Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair; ; ; ; ;
in Journal of Biological Chemistry (2011), 286(48), 41246-52
2009
Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans; ; ;
in Mechanisms of Ageing and Development (2009), 130(10), 670-80
2008
A second GDP-L-galactose phosphorylase in Arabidopsis en route to vitamin C covalent intermediate and substrate requirements for the conserved reaction; ; ; ; ;
in Journal of Biological Chemistry (2008), 283(27), 18483-92
L-Ascorbate biosynthesis in higher plants: the role of VTC2;
in Trends in Plant Science (2008), 13(11), 567-73
2007
Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants; ; ; ; ; ;
in Journal of Biological Chemistry (2007), 282(26), 18879-85
Vitamin C. Biosynthesis, recycling and degradation in mammals.;
in FEBS Journal (2007), 274(1), 1-22
2006
Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver;
in FEBS Journal (2006), 273(7), 1516-27
2004
A spectrophotometric assay of D-glucuronate based on Escherichia coli uronate isomerase and mannonate dehydrogenase;
in Protein Expression and Purification (2004), 37(2), 352-60
2003
Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes;
in Journal of Biological Chemistry (2003), 278(38), 36328-33
